What happens in the Late phase of an asthma attack?
There is an infiltration by TH cells, eosinophils and monocytes (from the immediate phase). These cause the release of mediators such as leukotrienes, adenosine and NO, which cause airway inflammation, airway hyperreactivity and bronchospasm. Toxic proteins such as ECP and EMBP are also released. These cause endothelial damage which contributes to airway hyperreactivity. The overall effect is wheezing, coughing, and a difficulty in breathing.