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- - Progressive chronic neurological disorder.- May develop @ any age- most common in 60s.
- - No cure for disease.
- - Therapy aimed at controlling symptoms.
- - Signs and symptoms relate to damaged neurons in the basal ganglia of the brain.
Theories of causes?
- -Viral infection.
- - Blows to the head.
- - Brain infection.
- - Atheroslerosis.
- - Exposure to drugs and environmental factors.
Causes of signs and sypmtoms?
In substantia nigra, a dopamine-rich area in the brain, nerve cell bodies begin to degenerate, resulting in a reduction of the number of impulses sent to the corpus striation in the basal ganglia.
Signs and symptoms of Parkinson's?
- - TRAP -Tremors -Rigidity
- -Position/ Posture
- -Lack of coordination.
- - Mask-like expression.
- - Problem walking
- - Drooling and affected speech.
- Levodopa (Dopar)- Antiparkinsonian- Dopaminergic Agent Sinemet (Carbidopa-Levodopa)
- - Dopaminergic Agent
Secondary symptoms of Parkinson's Disease?
- - Depression.
- - Sleep disturbances
- - Dementia
- - Forced eyelid closure
- - Drooling, dysphagia, constipation
- - Shortness of breath.
- - Urinary hesitancy and urgency.
- - Decreased sex drive.
- Act: carbidopa is an enzyme inhibitor which reduces the metabolism of levodopa
Therapeutic O/C for sinemet?
- -Dopamine agonist.
- -Establish a balance of dopamine and acetylcholine in the basal ganglia. Enhances delivery of dopamine to brain cells
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