Common Biological Response Modifiers

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Author:
tkayrm
ID:
166658
Filename:
Common Biological Response Modifiers
Updated:
2012-08-20 00:32:44
Tags:
BRM
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Description:
Common Biological Response Modifiers used as Supportive Cancer Therapy
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  1. Sangramostim (Leukine, Prokine)
    Chemotherapy-Induced leukopenia
  2. Filgrastim (Neupogen)
    Neutrophils (neutropenia)
  3. Pegfilgrastim (Neulasta)
    Neutrophils (neutropenia)
  4. Epoetin alfa (Epogen, Procrit)
    Erythrocytes (anemia)
  5. Oprelvekin (Neumega)
    Platelets (thrombocytopenia)
  6. Interleukins (IL-1 IL-2, IL-6)
    Help different immune system cells recognize and destroy abnormal cells.  Appear to charge up the immune system and enhance attacks on cancer cells by macrophages, natural killer (NK) cells, and tumor-infiltrating lymphocytes.
  7. Interferons
    • *Slow tumor cell division
    • *Stimulate the growth and activation of NK cells
    • *Help cancer cells¬† resume a more normal appearance and function
    • *Inhibit the expression of oncogenes
  8. Thalidomide (Thalomid)
    Reduce the level of tumor angiogenesis factor (TAF)

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