Adrenergic Rx

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Author:
emac0408
ID:
167327
Filename:
Adrenergic Rx
Updated:
2012-08-25 07:59:19
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Adrenergic Rx
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Description:
List of Adrenergic medications
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  1. Phenylephrine
    • Alpha-1 Agonist:  vasoC
    • -Tx:  Shock/hypoT, nasal decongestant (neosynephrine): rhinitis medicamentosa
    • -Mydriasis
    • -longer t1/2 (not a stubst for COMT)
    • -weak Beta effects
  2. Methoxamine
    • Alpha-1 Agonist:  vasoC
    • -Tx:  Shock/HypoT
    • -no Beta effect
    • -longer t1/2 (not stubstr for MAO/COMT)
  3. Clonidine
    • Alpha-2 Agonist:  AntiHT, vasoC
    • -Tx:  HT 
    • -Central SNS suppression via alpha2
    • -direct vasoC via alpha1
    • -Rebound HT
  4. Dobutamine
    • Beta-1 Agonist:  inotropic, vasoD
    • -Tx:  CHF
    • -stims Beta2 and alpha
    • -inotropic via B1
    • -vasoD via B2 predominates (preserves renal/GI flow)
    • -may devel tolerance
  5. Terbutaline
    • Beta-2 Agonist:  BronchoD
    • Tx:  Asthma/COPD 
    • inhalation reduces chances of Beta1 effect
    • mast cell inh.
    • long t1/2 (no COMT/MAO act.)
  6. Albuterol
    • Beta-2 Agonist:  BronchoD
    • Tx:  Asthma/COPD
    • inhalation reduces chances of Beta1 effect
    • mast cell inh.
    • long t1/2 (no COMT/MAO act.)
  7. Amphetamine
    • ^NE release
    • CNS stim
    • Anorexia
  8. Ephedrine
    • ^NE release + alpha/beta stimulation
    • BronchoD
    • Urinary incontinence (alpha1/beta2)
    • CNS stim
    • Anorexia
    • contraindication w/ Caffeine
  9. Metaraminol
    • ^alpha1 (weak beta) + "false NT" (uptake 1: replaces NE in granules)
    • Tx:  Shock/hypoT
  10. Phenoxybenzamine
    • Alpha Antagonist: irreversible block
    • Tx:  Pheochromocytoma, BPH, Autonomic Hyperreflexia
    • Side:  Orthostatic hypoT, nasal congestion, ejaculatory dysfx
  11. Phentolamine
    • Alpha Antagonist:  
    • Tx:  Pheochromocytoma, Erectile Dysfx (ED)
    • equal alpha affinity 
    • Sides:  OthroHypoT, Reflex Tachycardia (a2 block -FB), nasal congestion
  12. Prazosin
    • Alpha-1 Antagonist:  vasoD (arterial&venous return)
    • Tx:  AntiHT, BPH
    • "1st Dose Phenomenon":  OrthoHypoT
    • CNS effects possible?
  13. Propranolol
    • Beta Antagonist:  B1=B2
    • Tx:  AntiHT, Ischemic Heart Disease, Hyperthyroidism, Glaucoma
    • No effect on nl heart or BP at rest
    • Contraindicated with Asthma/COPD (B2 blocker) & Diabetics (hypoglycemia/inh tachycardia)
    • Sides:  hypoglycemia, bronchC, membrane stabilizing (suppress AP's)
  14. Metoprolol
    • Beta-1 Antagonist:  
    • Tx:  AntiHT, Ischemic Heart Disease
    • No effect on nl heart or BP at rest
    • Less likely to bronchoC
  15. Guanethidine
    • Sympatholytic:  replaces NE in vesicles & inh vesicle release
    • Tx:  AntiHT (dilates arterial & venous)
    • t1/2= 5 days
    • Little CNS effect
    • Contraindicated with MAOI's
    • Sides:  OrthoHypoT, GI/diarrhea, Male sexual dysfx (retrograde ejac)
  16. Reserpine
    • Sympatholytic:  irrev inh VMAT (inh E/NE/DA uptake to vesicles), blocks NE storage/synthesis (DA-B-hydroxylase in vesicles)
    • t1/2=weeks
    • Tx:  AntiHT, antipsychotic (rarely used)
    • Sides:  CNS effects (depress., sedation, suicide)
  17. Methyl Tyr
    • Inh Catecholamine Syn:  inh Tyr Hydroxylase
    • Tx:  pre-op Pheochromocytoma
    • Sides:  SNS depression, Sedation, Anxiety
  18. a-Methyldopa
    • Alpha agon False NT:  metab to a-methyl-NE 
    • Tx:  AntiHT (Central SNS depression via alpha2)
    • Spares renal flow
    • Preferred in HT pregnancy
    • Sides:  CNS effects (sedation)
  19. Cocaine
    Uptake 1 Inh.  (^NE in synaptic cleft)

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