Stem Cells

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What is current dogma regeneration of nervous system?

Can't happen, but did happen in a limited fashion in one patient
What part of the brain did limited neurogenesis occur?

hippocampus
Stem cell definition?
- Divides asymmetrically
- Can regenerate itself
- generates all cell types in that tissue
Totipotent, Pluripotent, and Multipotent stem cells?

Toti: generates all cell types and placenta (capable of forming an entire organism)

Pluri: generates all cells of organism EXCEPT for placenta

Multi: generates multiple cell types but not all
Which is toti, multi, pluri? Zygote, embryonic stell cell.
- Zygote = Totipotent
- ESC = Pluripotent
2 Cellular therapy for stroke?
- 1. Neural stem cells (NT2N and c-mycER)
- 2. bone-marrow derived stem cells (MPC Athersys)
iPS?

Fibroblast plus 4 other genes and NANOG cause it to be transformed into induced-pluripotent stem cell