The large intestine and disorders
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What is the function of the large intestine?
- Absorb water
- Immune function
Outline the immune function of the GIT.
- Oral tolerance.
- New foods taken in, that would cause an immune response if injected.
- Mucosal immune cells bind the antigens and take them into the blood, signalling to the CNS that they are safe.
- The epithelial cells provide a barrier so that the antigens can't enter the blood on their own.
- Gut is in a constant state of controlled inflammation.
What happens in inflammatory bowel disease?
The antigens flood through the leaky epithelial cells and cause an immune response, releasing TGFa , a proinflammatory agent that promotes massive inflammation. This inflammation causes further epithelial damage.
Name 3 treatments of IBD.
- 1. Glucocorticoids
- -general anti inflammatories
- 2. Anti- TNFa drugs
- -monoclonal antibodies bind TNFa and neutralises it
- 3. Sulfosalazine
- -high efficacy
- -mechanism unknown
Name examples of inflammatory bowel diseases.
- Crohn's Disease
- Ulcerative Colitis
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