Clinical Aspects of Viral Hepatitis (Dr. Ebright)

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davis.tiff
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168450
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Clinical Aspects of Viral Hepatitis (Dr. Ebright)
Updated:
2012-09-02 22:06:02
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MICROBIOLOGY INFECTIOUS DISEASES
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Description:
MICRO/ID EXAM III
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  1. Which hepatitis viruses are most commonly involved in infectious hepatitis?
    Hepatitis A, B, and C
  2. What can cause non-infectious hepatitis?
    • 1) Drugs/medications
    • 2) Alcohol
    • 3) Cholecystitis
    • 4) Obstructed bile duct
  3. What are the 4 clinical stages of viral hepatitis?
    • 1) incubation
    • 2) preicteric
    • 3) icteric
    • 4) convalescence
  4. What are the 7 most common symptoms of viral hepatitis?
    • 1) Malaise
    • 2) weakness
    • 3) anorexia
    • 4) N/V
    • 5) dull RUQ pain
    • 6) low-grade fever
  5. True or false. Jaundice is not usually associated with viral hepatitis.
    True
  6. Jaundice, dark urine and light stool occur with _____ hepatitis.
    icteric
  7. What is the most distinctive characterisitic of viral hepatitis?
    elevated AST and ALT 
  8. True or false. Prothrombin time, albumin, globulin, hemoglobin and WBC count are usually abnormal in patients with acute hepatitis disease.
    False, prothrombin time, albumin, globulin, hemoglobin and WBC count are usually normal in patients with acute hepatitis disease.
  9. What are some of the pathologic findings in acute viral hepatitis?
    • Disorderly pattern of sinusoidal cords
    • Ballooning and eosinophilic degeneration of liver cells
    • Spotty necrosis
    • Lymphocyte infiltration, primarily in portal tracts
    • Cholestasis
  10. Which hepatitis viruses are most involved in chronic hepatitis?
    Hepatitis B and C
  11. Which hepatitis virus is most commonly developed in infants? Adults?
    Hepatitis B virus; Hepatitis C
  12. How does chronic viral hepatitis differ from acute viral hepatitis?
    It is the same, except for abnormal liver function tests and liver biopsy
  13. In _____ hepatitis, the patient is often positive for "e" antigen, HBV DNA, and DNA polymerase.

    A. acute B. chronic
    B. chronic
  14. Which viral hepatitis type is usually transmitted via fecal-oral route?
    HAV, HEV
  15. Which viral hepatitis type is non-enveloped?
    HAV, HEV
  16. If you are protected against HBV, which other hepatitis virus are you also protected against?
    HDV
  17. Which hepatitis virus is the only one with a DNA genome?
    HBV
  18. Match the following.

    1. HAV
    2. HBV
    3. HCV
    4. HDV
    5. HEV

    A. Hepadnaviridae
    B. Flaviviridae
    C. Picornavirus
    • 1. C
    • 2. A
    • 3. B
  19. Pregnant women infected with HEV is at an increased risk for developing which type of hepatitis?
    Fulminant
  20. Which hepatitis virus(es) has an insidious onset pattern?
    • 1. HCV
    • 2. HBV (insidious and acute)
  21. Which hepatitis virus(es) can present with cirrhosis as a result of a prolonged infection?
    HBV (and HDV), HCV
  22. What hepatitis virus can be diagnosed with presence of IgM anti-Hbc?
    HBV
  23. What hepatitis virus can be diagnosed using quantitative PCR?
    HCV
  24. What hepatitis virus can be diagnosed with presence of IgM anti-HAV?
    HAV
  25. Which hepatitis virus can provide protection using immune globulin?
    HAV and HBV (passive immunity)
  26. Which hepatitis virus is the only one that does not have an available vaccine?
    HCV
  27. Which hepatitis virus can be treated with interferon-alpha and antivirals?
    HBV (and HDV) and HCV
  28. Name the major difference between alcoholic hepatitis and acute hepatitis?
    • Alcoholic acute
    • Elevated AST
    • Acute hepatitis
    • Both AST and ALT are elevated
  29. True or false. You can measure and detect core anitgen for diagnosis.
    False, you cannot measure and detect core anitgen for diagnosis.
  30. What is the "window period"?
    Period in which virus cannot be detected in lab

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