Gastrointestinal Agents

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  1. What are the three types of gastric ulcers?
    • 1. Erosion
    • 2. Acute
    • 3. Perforated 
  2. What does GERD stand for?
    Gastricesophageal reflux disease
  3. Which type of an ulcer is a medical emergency?
    Perforated
  4. What types of gastric or gastrouodenal contents are regurgitated during GERD?
    • H+
    • Pepsin
    • Bile Acids
    • Pancreatic enzymes
  5. What types of people does GERD occur in?
    • Infants
    • Children
    • Pregnant Women
    • >40
  6. GERD causes injury to what?
    Lumen of the esophagus
  7. What drugs lower the esophageal sphincter tone?
    • Ca+2 channel blockers
    • Nitrates
    • Theophylline
    • Anticholinergics
    • Narcotics
    • Beta-agonists
    • estrogen
    • progesterone 
  8. What drugs are direct irritants to the esophagus?
    • NSAIDS
    • K+ supplements
    • bisphosphonates
  9. What are some common clinical presentations of GERD?
    • Heartburn
    • hyper-salivation
    • belching
    • vomiting/regurgitation
  10. What are some atypical presentations of GERD?
    • Chest pain
    • Hoarsness
    • Throat tightness
    • Asthma
    • Chronic Cough
    • Hiccups
    • Recurrent otitis in children
    • Lingual dental erosion
  11. Whata re some severe presentations of GERD?
    • Erosion
    • Continual Pain
    • Stricture/spasm
    • Barrett's esophagus (adenocarcinoma risk greatly increased)
  12. What are signs of pediatric GERD?
    • Cough at night
    • Complain of abdominal pain
    • Refuse to eat
    • Have bad taste in mouth
    • Spit-Up
  13. What are some treatment options for GERD?
    • Lifestyple changes (no alcohol or tobacco)
    • Avoiding certain foods
    • Eat 4-6 hours before sleeping
    • Antacids
    • H2 blockers
    • PPI
  14. What acts as a buffer in the stomach?
    Bicarbonate
  15. What are the three steps in healing ulcers?
    • Exfoliation
    • Restitution
    • Recovery
  16. People with GI bleeds caused by ulcers may have what two presentations?
    • Iron-deficiency anemia
    • Foul odored stool containing blood
  17. What causes GERD?
    Helicobacter pylori (H. pylori)
  18. Who discovered that GERD is caused by bacteria not stress?
    • Barry Marshall 
    • J. Robin Warren
  19. What type of bacteria is H. pylori?
    Gram negative rod
  20. How many people have H. pylori infections?
    About 50% worldwid, increasing with age
  21. Why can H. pylori survive in the stomach?
    • Adhere to GI cells by HpaA adhesion protein 
    • can utilize urea and convered it to carbon dioxide and ammonia, ammonia allows bacteria to penetrate the mucous layer
  22. What is the cold standard 

Card Set Information

Author:
ANVigil
ID:
168567
Filename:
Gastrointestinal Agents
Updated:
2012-09-02 22:14:49
Tags:
Gastrointestinal Agents Med Chem Quiz
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Description:
Gastrointestinal Agents, Med. Chem 2, Quiz 1
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