Card Set Information
What is the function of vitamin A?
Constituent of visual pigments
essential for normal differentiation of epithelial cells into specialized tissue (pancreatic cells, mucus-secreting cells)
What is seen with vitamin A deficiency?
lung -> squamos epithelium
What is seen with vitamin A excess?
Arthragias, fatigue, headaches, skin changes, sore throat, alopecia. Teratogenic
What is the function of Vitamin B1
Pyruvate dehydrogenase (glycolysis)
a-ketoglutarate dehydrogenase (TCA cycle)
Transketolase (HMP shunt)
Branched-chain AA dehydrogenase
What is seen with a vitamin B1 deficiency?
Impaired glucose breakdown -> ATP depletion
Wernicke-Korsakoff (confusion, opthalmplegia, ataxia, confabulation)
Dry beriberi = polyneuritis, symmetrical muscle wasting
Wet beriberi = high output cardiac failure (dilated cardiomyopathy), edema
What is the function of vitamin B2?
Cofactor in oxidation and reduction (FADH2 and FMN)
Succinate dH (TCA)
fatty acyl dH (B-oxidation)
Glycerol dH (electron from cytoplasm to mitochondria)
What is seen with a vitamin B2 deficiency?
Cheilosis, corneal vascularization
What is the function of vitamin B3?
Derived from tryptophan with vitamin B6
Constituent of NAD+ & NADP+
What is seen with a vitamin B3 deficiency?
Pellagra (Diarrhea, Dermatitis, Dementia) from
Hartnup disease (decrease tryptophan absorption)
malignant carcinoid syndrome (increased tryptophan metabolism)
INH (decrease vitamin B6)
What is seen with a vitamin B3 excess?
Facial flushing (when given for hyperlipidemia treatment)
What is the function of vitamin B5?
Essential component of CoA and fatty acid synthase
Fatty acyl CoA synthase
What is seen with a vitamin B5 deficiency?
What is the function of Vitamin B6?
PYRIOXINE (converted to pyridoxal phosphate)
synthesis of niacin from tryptophan
What is seen with a deficiency in Vitamin B6?
peripheral neuropathy(INH & oral contraceptives)
sideroblastic anemias, cheilosis
What is the function of vitamin B 12?
cofactor for homocysteine methyltransferase and methylmalonyl-CoA mutase
What is seen with a vitamin B12 deficiency?
Macrocytic, megaloblastic anemia
neurologic (paresthesias, subacute combined degeneration) due to abnormal myelin