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2012-09-03 23:06:36

Neurotransmitter Functions
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  1. Function of Glutamate
    • In the hippocampus - glutamate activity is critical in the formation of memory
    • Glutamate is the major excitatory neurotransmitter
  2. Function of GABA
    • the major inhibitory neurotransmitter in the CNS
    • Role - inhibition of excitatory neurons in the cortex and thalamus
  3. Function of Dopamine
    plays a role in mood disorders, psychosis, Parkinson's disease, fear response, and drug addiction
  4. Function of Dopamine in the Nigrostriatal Tract
    Involved in regulation of muscle tone
  5. Function of Dopamine in the Tuberoinfundibular tract
    Normally, dopamine inhibits secretion of prolactin from the anterior pituitary
  6. Function of Dopamine in the Mesolimbic / mesocortical tract
    plays a role in psychosis and mood disorders due to extensive projections into limbic system and prefrontal cortex
  7. Function of Norepinephrine
    • Plays a role in mood, anxiety, arousal, learning, and memory formation
    • Norepinephrine levels are low in depression and high in anxiety disorders
  8. Function of Serotonin
    • Serotonin in proper amounts = feelin' good
    • Low Serotonin = depression and anxiety
    • Too high Serotonin = psychosis and/or euphoria
  9. Function of Acetylcholine
    • Modulates attention, novelty seeking, and memory via forebrain projections to cortex and limbic system
    • Regulation of sleep-wake cycle via brainstem projections to the thalamus
  10. What causes Depression?
    • low serotonin
    • low dopamine
    • low norepinephrine
  11. What causes Mania?
    Too much dopamine!!!!
  12. What causes Psychosis
    • Too much dopamine
    • too much serotonin
    • too much glutamate
  13. What causes anxiety?
    • low serotonin
    • low GABA
    • too much norepinephrine
  14. What causes dementia?
    • low acetylcholine
    • too much glutamate