True or False. Retrovirus have a both a simple and complex RNA genome.
Describe the simple RNA genome of retroviruses.
Contains gag (CA, NC, MA), pol (PR, RT, IN) and env (SU, TM) genes
Describe the complex RNA genome of retroviruses.
Contains gag (CA, NC, MA), pol (PR, RT, IN) and env (SU, TM) genes, in addition to vif, tat, vpr, vpu, rev and nef genes.
What is the replication cycle of retroviruses?
virus binds to CD4 receptor and co-receptor on CD4+ T cell > fuses then penetrates and invades cell > viral RNA is transcripted via reverse transcriptase > dsDNA is produced > ligation > integration into host DNA > transcription of host DNA with viral genes > ssRNA (viral mRNA + progeny RNA) > translation of viral proteins > assembly of nucleocapsid > budding and release
What are the 3 types of retroviral RNA that are transcribed upon infection of the host?