S4M1 pharm

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Author:
Anonymous
ID:
169341
Filename:
S4M1 pharm
Updated:
2012-09-06 19:50:49
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S4M1 pharm
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Description:
S4M1 pharm
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  1. hyperactivity
    prefrontal motor cortex
  2. impulsivity
    orbital frontal cortex, linked to nucleus accumbens
  3. selective attention
    dorsal anterior cingulate cortex (ACC)
  4. sustained attention
    dorsolateral prefrontal cortex
  5. Atomoxetine
    • SNRI ==> tx of ADD
    • - cyp450 inhib (paroxetine)==> inc [drug]pl
    • - reversible liver injury (rare)
  6. Guanfacine XR
    • a-2 agonist (CNS)
    • ADD, esp if tics present
  7. Ezogabine
    • dampen neuronal hyperexcitability via blockade of certain voltage-gated K channels
    • adjunct tx in drug res. patial seizures

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