Treatment of GU Infections (Dr. Pogue)

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  1. What organism is most targeted in cystitis treatment? What is the drug(s) of choice and duration of treatment?
    E. coli; Bactrim (3 days); beta-lactams (5-7 days)
  2. What drug has a mechanism of action that involves inihibition of enolpyruvate transferase which inhibits cell wall synthesis, has Gram- coverage, is given in 1 large dose, maintains high concentrations in the urine for 48 hours, and can be used in pregnancy??
    Fosfomycin
  3. What organism is most commonly involved in community-acquired pyelonephritis? What is the best oral treatment used and duration of treatment?
    E. coli; ciprofloxacin (FQ); 7-10 days (but longer in complicated UTIs)
  4. What organism is most commonly involved in community-acquired pyelonephritis? What is the best IV treatment used?
    E. coli; Ciprofloxacin (FQ)
  5. What organism is most commonly involved in hospital-aquired (healthcare-associated) pyelonephritis? What are the best types of treatment to use?
    P. aeruginosa; antipseudomonals (cefepime or ceftazadime, piperacillin/tazobactum, ciprofloxacin (FQs), meropenem, imipenem, doripenem (group 2 carbepenems), gentamycin (aminoglycosides))
  6. True or false. Asymptomatic bacteriuria should not be treated unless pregnancy, neonates, UT instrumentation or renal transplants are involved.
    True
  7. True or false. Candiduria is always represented as a colonization rather than an active infection.
    True
  8. What 3 STDs have genital ulcer conditions?
    • chancroid
    • genital herpes
    • syphilis
  9. What 2 STDs involve urethritis and cervicitis?
    • Chlamydia
    • Gonorrhea
  10. What is the causative agent for Chancroid?
    Haemophilus ducreyi
  11. True or false. Chancroid is characterized by painless ulcers and there is a possibility for co-infection with HSV and syphilis.
    False, Chancroid is characterized by painful ulcers and there is a possibility for co-infection with HSV and syphilis.
  12. What is the drug of choice for Chancroid?
    Azithromycin in 1 dose
  13. What is the main drug of choice for all stages of Syphilis?
    Penicillin
  14. What is the drug of choice for disseminated genital herpes (HSV)? Duration of treatment?
    IV acyclovir; 10 days
  15. What is the drug of choice for genital herpes (HSV)? Duration of treatment?
    Valcyclovir (acyclovir); 7-10 days
  16. What drug can be used for the treatment of the primary and secondary phases of Syphilis?
    Benzathine penicillin in 1 dose
  17. What 3 drugs can be given for treatment of primary or secondary Syphilis if there is a hypersensitivity reaction to penicillin?
    • doxycycline
    • ceftriaxone
    • azithromycin
  18. What is the treatment regimen for the treatment of the latent and tertiary phases of Syphilis?
    Benzathine penicillin, or doxycycline, ceftriaxone or azithromycin if there is a hypersensitivity reaction; 3 doses at 1-week interval
  19. What is the treatment regimen for neurosyphilis? What if there are complications to this treatment?
    Aqueous crystalline penicillin; IM dose of aqueous crystalline penicillin with Probenecid
  20. What is Jarisch-Herxheimer and how is it treated?
    reaction seen soon after Syphilis treatment; inflammatory agents
  21. What is the drug of choice for Chlamydia? What is another drug option and what is the duration of treatment?
    Azithromycin in 1 dose; doxycycline for 7 days
  22. What is the drug of choice for uncomplicated Gonorrhea?
    ceftriaxone in 1 dose
  23. What is the drug of choice for disseminated Gonorrhea?
    IV 3rd generation cephalosporins
  24. True or false. If treating for Gonorrhea, Chlamydia should also be treated.
    True
  25. What are the 3 main catergories for Vaginosis?
    • bacterial
    • trichomoniasis
    • candiasis
  26. What is the best treatment for T. vaginalis?
    Metronidazole in 1 dose
  27. What are the 5 organisms involved in Pelvic Inflammatory Disease (PID)?
    • N. gonorrhea
    • C. trachomatis
    • Some Gram- organisms
    • Anaerobes
    • Streptococcus (maybe)
  28. What is the empiric recommendation(s) for Pelvic Inflammatory Disease IV treatment?
    • Cefotetan or cefoxitin with doxycycline
    • Clindamycin with gentamycin
  29. When would you use oral therapy for Pelvic Inflammatory Disease?
    • In mid-moderate disease
    • After response to initial IV therapy
  30. What are the 2 main organisms involved in epididymitis (via vaginal intercourse)?
    • C. trachomatis
    • N. gonorrhea
  31. What are the 2 main organisms involved in epididymitis (via anal intercourse)?
    • E. coli
    • P. aeruginosa
  32. What is the best treatmnent for epididymitis (via vaginal intercourse)?
    Ceftriaxone with doxycycline
  33. What is the best treatmnent for epididymitis (via anal intercourse)?
    Ciprofloxacin (FQs)

Card Set Information

Author:
 davis.tiff
ID:
 169529
Filename:
 Treatment of GU Infections (Dr. Pogue)
Updated:
2012-09-09 02:28:16
Tags:
MICROBIOLOGY INFECTIOUS DISEASES
Folders:

Description:
MICRO/ID EXAM III
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