antiplatelets

Card Set Information

Author:
baseball4life189
ID:
170630
Filename:
antiplatelets
Updated:
2012-09-13 03:50:35
Tags:
asa p2y12 g2b
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Description:
MOA/indications
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  1. Aspirin
    MOA: inhibition of COX-1 which inhibits TXA2 (very slight inhibition of COX-2 170:1 ratio)

    • Indications:
    • 1o ppx of coronary events (recently questioned)
    • 2o ppx in pts with hx of acute MI, post MI, & UA
    • Post CABG surgery
    • Pre and post tx of coronary angioplasty/stent (PCI)
    • Combo tx with plavix for UA and post PCI/stent procedure
    • Ppx for stroke d/t cardioembolic embolism 2o to a. fib
    • Ppx of non-cardioembolic (lacunar) stroke, TIAs, peripheral vascular disease
  2. Ticlopidine
    Thienopyridine Agent
    MOA: Irreversibly inhibits the binding of ADP to its receptors (P2Y12 and P2Y1) on the platelets which inhibits transformation of GPIIb/IIIa receptor into its active form

    • Indications: 
    • Post ACS (UA/NSTEMI), post PCI/stent
    • Combo tx with asa for PCI/stent
    • Ppx of stroke/TIA in patients unable to take ASA
  3. Clopidogrel
    Thienopyridine Agent
    MOA: Prodrug with two pathways. Irreversible binding to platelets which inhibits ADP binding to platelet receptors (P2Y12)

    • Indications:
    • Alternative to ASA if ASA is CI
    • Ppx in high-risk pts with arterial thromboembolism
    • Stroke ppx in patients with noncardio-embolic TIA or stroke
    • Cardio-embolic stroke prevention (with ASA) d/t a. fib when oral anticagulants cannot be taken
    • ACS (UA/NSTEMI/STEMI)
    • Combo tx with ASA post PCI/stent placement

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