This type of diabetes is the more common type where muscle, fat, liver cells fail to respond to insulin and this form of diabetes is frequently asymptomatic. The primary defect in ______ diabetes is insulin resistance, a reduced sensitivity to insulin in muscle, adipose, and liver cells. To compensate, the pancreas secretes larger amounts of insulin, and plasma insulin concentrations can rise to abnormally high levels (hyperinsulinemia). Over time, the pancreas becomes less able to compensate for cells' reduced sensitivity to insulin, and hyperglycemia worsens. The high demand for insulin can eventually exhaust the β-cells of the pancreas and lead to impaired insulin secretion and reduced palsma insulin concentrations. ______ diabetes is therefore associated both with insulin resistance and with relative insulin deficiency.
Type II Diabetes / NIDDM / Adult-onset