lecture 3 - V1.txt

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jselim
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171127
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lecture 3 - V1.txt
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2012-09-16 09:25:40
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  1. IL-1
    • Monocytes/macrophages
    • 1. autocrine activation
    • 2. T-cells stimulated to secrete IL2
    • 3. pyrogen – feaver
    • 4. B-cell proliferation
    • 5. acute phase protiens by the liver
    • 6. Second signal for t cell activation
  2. IL-2
    • TH1 CD4+ T-cells
    • 1. autocrine
    • 2. Proliferation and differentiation of activated T,B or NK cells
  3. IL-4
    • TH2 CD4+ T cells
    • 1. Second signal for B cell activation
    • 2. B-cell proliferation
    • 3. B-cell AB class switching
  4. IL-7
    • Thymic cortical epithelial cells/Bone Marrow Strom
    • 1. T/B cell proliferation during development
  5. IF-alpha/Beta
    • All cells (monocytes, fibroblasts)
    • 1. Induces “antiviral state”
    • 2. Activates NK cells
  6. IF-Gama
    • T cells and NK cells
    • 1. induces antiviral state
    • 2. activates NK cells
    • 3. class switching to IgG2,3
    • 4. Macrophage activation
  7. Chemokines
    • CC – attracts monocytes and T cells
    • CXC – attracts neutrophils (IL-8)
  8. TNF – alpha
    • Many cells
    • 1. Up-regulate adhesion molecules on epithelial cells
    • 2. directly kill tumor cells
    • 3. activate monocytes and macrophages
  9. TNF – Beta
    • T and B cells
    • 1. Up-regulate adhesion molecules on epithelial cells
    • 2. directly kill tumor cells
    • 3. activate monocytes and macrophages
  10. Emigration of Naive T cells to secondary lymph tissues
    • endothelial cells express P-selectin and E-selectin
    • 1. Rolling adhesion – L selectin on Leukocytes to P/E
    • 2. Tight binding by integrins
    • 3. Diapedisis
    • 4. Migration
  11. CD4 T cell activation
    • 1. Antigen/MHCII
    • 2. B7/IL-1 by activated Macrophage
    • → B7 binds CD28 on t cell
  12. CD28
    • T cell surface
    • Binds B7
    • Second activation signal
  13. anergic
    • non-responsive t cell after receiving only one signal
    • Peripheral tolerance
  14. Superantigens
    • Non-specific
    • not processed
    • cause massive cytokine release
    • binds outside the cleft
    • fever nausea shock
  15. TH1 differentiation
    • IL-12
    • IFN-Gama
    • TGF-beta
  16. TH1 secretions
    • Cell mediated immunity (CD8 t cells)
    • IL-2
    • IFN gama
    • TINF-beta
  17. TH2 differentiation
    • IL-4
    • IL-10
  18. TH2 secretions
    • B cells (hormonal immunity)
    • IL-4
    • IL-5
    • IL-6
    • IL-13
  19. Delayed type hypersensitivity
    • TH1 activate macrophages (free radicals and nitric oxide) and Neutrophils and lymphocytes
    • activated macs don't care what they're destroying → self

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