Lecture 2 - MHC + TCR.txt

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jselim
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171129
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Lecture 2 - MHC + TCR.txt
Updated:
2012-09-16 09:26:36
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  1. The 4 classes of immunoglobulin super family
    • MHC1
    • MHC2
    • TCR
    • AB
  2. MHC1 structure
    • like a pita pocket
    • 1 alpha chain – 3 domains
    • 1+2 = binding pocket
    • Beta 2 microglobulin – co protein not anchord
    • CD8 t cells
    • 8-10 AA in length
  3. MHC2 structure
    • two chains
    • beta and alpha 2 in the mem
    • CD4
    • non-covalent association
    • 13-20 aa in length
  4. MHC1 is found on
    all nucleated cells
  5. MHC2 is found on
    • APC
    • Microglia
    • thymic stromal cells
  6. APC are
    • macrophages/monocytes
    • B cells
    • Dendritic cells
  7. HLA complex
    • MHC gene
    • Polygenic
  8. MHC1 Loci
    • A – alpha
    • B – alpha
    • C – alpha
    • you can have up to 6 different MHC1
  9. MHC2 Loci
    • DP – beta alpha
    • DQ – beta alpha
    • DR – beta alpha
    • you can have up to 12 different MHC2s
  10. involved in Cytosolic pathway
    • endogenous
    • host protein
    • intracellular pathogen – viral dna
    • MHC1
    • CD8
    • Cytotoxic
  11. involved in Endocytic pathway
    • Microbe
    • toxin
    • extracellular self protein
    • MHC2
    • CD4
    • inflamation
  12. cytosolic pathway steps
    • cytosolic protein gets ubiquinated
    • goes to the proteasome gets degraded into correct size
    • TAPs move it into the ER
    • Calnexin and Calreticulin associate the protein with MHC1
    • moves to the surface
  13. Endocytic Pathway
    • extracellular proteins are phago
    • degraded in phagolyso
    • invariant chain (Ii) keeps MHC2 clear
    • binds with phagolyso
    • invariant degrades
    • calnexin helps protein into place
    • presented on cell surface
  14. cytokines
    • small soluable proteins that deliver signals
    • paracrine – short distance
    • autocrine – self signaling
  15. TCR co protein
    CD3 complex → three double proteins
  16. Thymocyte
    developing t cell with no TCR
  17. Gene rearrangement is the first step in t cell development
  18. steps in TCR formation
    • alpha surrogate (pre-TCR)
    • double positive
    • TCR and CD3
    • Positive selection

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