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How does Acetyl CoA impact gluconeogenesis?
It allosterically activates hepatic pyruvate carboxylase.
What is the effect of high Acetyl CoA in the cytosol?
It increases de novo lipogenesis.
What is the effect of high Acetyl CoA in the mitochondria?
It slows the TCA cycle and inhibits PDH.
Why does someone with insulin resistance have elevated fasting glucose?
Insulin inhibits glycogenolysis and gluconeogenesis.
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