Med. Chem Test 1

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Anonymous
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171307
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Med. Chem Test 1
Updated:
2012-09-16 20:42:45
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Gastrointestinal agents CV packet
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Gastro and CV
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  1. Interventional cardiac device for treatment of bradycardia/conduction issues/arrhythmias
    Biventricular pacer/defibrillator
  2. Highly potent sulfonamide containing loop diuretic agent that inhibits the Na+/K+/Cl- carrier system primarily in the loop of henle (Lasix)
    Furosemide
  3. Reactivates intermediate compound that has been shown to acylate various proteins such as fribronectin and cytochrome C altering their function leading to a "thrombotic tendency" to form blood clots
    Homocysteine thiolactone
  4. A means of comparing two diuretics as a ratio of "equi-effective doses"
    Relative potency
  5. Target blood pressure goal for anti-hypertensive therapy
    120/80
  6. A diuretic which produces osmosis in the proximal convoluted tubule
    Mannitol-Osmitrol
  7. Loop diuretic of choice in patients that have a sulfonamide allergy
    Ethacrynic acid-Edecrin
  8. Biomarker advanced glycation end product used to measure blood glucose control
    Hemoglobin A1c
  9. Carbonic anhydrase inhibitor used in glaucoma, altitude sickness, edema, epilepsy
    Acetazolamide
  10. This type of apnea leads to increased hypoxia and has been shown to increase the risk of developing CV disease
    Sleep disorder breathing
  11. Cation electrolyte that is the primary force that leads to increased retition of water
    Na+ (Sodium)
  12. Anatomical kidney location where the most efficacious diuretics act
    Thick ascending loop of henle
  13. Neurotransmitter causing hypertension and left ventricular remodeling
    Norepinephrine
  14. Maximal urine volume or loss of NaCl per unit time
    Efficacy of a specific diuretic
  15. Acute phase inflammatory protein that binds phosphocholine groups in cell membranes leading to damage form complement activation
    hsCRP
  16. OTC diuretic agent and urinary acidifier used to treat menstrual discomfort of bloating and premenstrual syndrome
    NH4Cl & Caffeine
  17. Amount of a diuretic drug (mg/kg) needed to produce a desired biological effect-controlled by absorption, distribution, biotransformation, excretion and intrinsic activity at its receptor
    Potency of a drug
  18. Excessive loss of K+ which can increase the toxicity of the cardiac glycosides such as digoxin
    Hypokalemia
  19. Most potent of all the loop diuretics (40X that of furosemide)
    Bumetanide-Bumex
  20. Elevated levels of this amino acid was once considered a biomarker for CV disease-it is not a cause but a contributor to the disease state
    Homocysteine
  21. Antagonist of the H2 histamine receptor and is a powerful inhibitor of CYP450 metabolic enzymes
    Cimetidine-Tagamet
  22. Treatment of hyperphosphatemia in end-stage renal disease
    Lanthanum carbonate-Fosrenol
  23. Saline laxative that should be used in caution in patients that have issues with severe salt-sensitive hypertension
    Na2PO4
  24. Intestinal lipase inhibitor used for treatment of obesity
    Orilstat-Xenical
  25. Use caution in chronic use of this antacid/laxative by patients with chronic renal failure
    Mg(OH)2- Milk of Magnesia
  26. Azo prodrug of 50aminosalicylic acid used to treat chronic inflammatory bowel diseases
    Olsalazine sodium-Dipentum
  27. Anticholinergic agent used to decrease Gi secretions/acid-decreased ability to cross the blood brain barrier resulting in CNS side effects since it is a quernary compound
    Proantheline- Pro-Banthine
  28. Blocks peripheral GI mu-opioid receptors-restores bowel function in patients receiving continuous narcotics for pain relief
    Methylnaltrexone bromide- Relistor
  29. Diphenylmethane class of stimulant/irritant laxative
    Bixacodyl-Dulcolax
  30. Extensive first-pass metabolism limits systemic availability-glucocorticoid for treatment of Crohn's disease
    Budesonide- Entocort EC
  31. Replacement therapy for use in ASA/NSAID induced gastric ulcers in patients that must take these drugs for other diseases such as rheumatoid arthritis
    Misoprostol-Cytotec
  32. Sufactant used to preven mucus-surrounded gas pockets to relieve digestive tract gas-miracle agent for gas and crying babies
    Simethicone-Mylicon
  33. Antagonist of the H2 histamine receptor and does not inhibit CYP450 metabolic enzymes
    Famotidine-Pepcid
  34. Monoclonal antibody against TNFalpha used to treat Crohn's disease
    Infliximab-Remicade
  35. Non-laxative approach to treating IBS chronic idiopathic constipation, selective Cl- channel activator of the GI tract with no effect on Na+/K+
    Lubriprostone- Amitiza
  36. Inhibits the muscles of the intestinal wall resulting in decreased GI motility that allows increased water absorption in diarrheal states
    Loperamide HCl- Imodium
  37. Anticholinergic agent used to decrease GI secretionsacid-readily crosses the blood brain barrier resulting in CNS side effect
    Scopolamine HBr- Scopase
  38. Sensitizes GI tissues to the effects of acetlycholine leading to increased peristalsis/GI emptying and increased esophageal sphincter pressure in GERD
    Metoclopramide- Reglan
  39. Treatment of diarrhea by noninvasive strains of E. coli and for treatment of hepatic encephalopathy
    Rifaximin-Xifaxan
  40. Proton pump inhibitor suitable for patients with apolymorphism in the CYP2C19 enzyme resulting in elevated levels of the drug
    Esomeprazole Magnesium- Nexium

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