Home > Preview
The flashcards below were created by user
on FreezingBlue Flashcards.
Choclate agar with factors V and X
Tellurite plate, Loffler's media
MacConkeys agar - pink colonies
Lactose fermenting enterics
Charcoal yeast extract buffered with cysteine
Why are aminoglycosides ineffective against Clostrridium, bacteroides, and actinomyces?
These anaerobes and aminoglycosides require O2 to enter into bacterial cells.
What are the facultative intracellular bugs?
Some Nasty Bugs May Live FacultativeLy
What are the encapsulated bacteria?
- Strep pneumo
- Klebsiella pneumo
- Haemophilus influenzae type B
- Neisseria meningitidis
- group B strep
Positive Quellung reaction
Urease positive bugs
- H. pylori
Protein A MOA and organism
Binds Fc region of Ig. Prevents opsonization and phagocytosis
IgA protease MOA and organism
Cleaves IgA in order to colonize respiratory mucosa
- Strep pneumo
- H. Influenza type B
M protein MOA and organism
- Prevent phagocytosis
- Group A streptococcus
What are the ADP ribosylating A-B toxins
- Corynebacterium diphtheriae:
- - inactivates elongation factor
- Vibrio Cholerae:
- - ADP ribosylation of G protein stimulates adenylyl cyclase: increase pumping of Cl- into gut and decrease Na+ absorption.
- E. Coli:
- - Heat labile toxin stimulates Gs protein -> Adenylate cyclase
- Bordetella pertussis:
- - Increases cAMP by inhibiting Ga1
Toxin of Clostridium perfringens
- Alpha toxin
- - a lecithinase that acts as a phospholipase to cleave cell membranes and causes gas gangrene.
Toxin of shigella
- Shiga toxin
- - cleaves host cell rRNA (inactivates 60S ribosome)
- - enhances cytokine release causing hemolytic uremic syndrome
- Group B streptococci, B-hemolytic
- Bacitracin resistant
- colonizes vagina
- causes pneumonia, meningitis, and sepsis
- Affects babies
Pregnant women + get intrapartum penicillin prophylaxis
Enterococci (Group D strep)
Normal colonic flora that are penicillin G resistant and cause UTI and subacute endocarditis
Grow in 6.5% NaCl and bile
Diphtheria toxin exotoxin encoded by B-prophage - inhibits protein synthesis via ADP ribosylation of EF-2
DX: via tellurite agar -> metachromatic granules
4 types of Clostridia
1. C. tetani- tetanospasmin causes spastic paralysis
2. C. botulinum- preformed heat-labile toxin that inhibits ACh release at NMJ
3. C. perfringens- a toxin(lecithinase) causes myonecrosis and hemolysis
4. C. difficile- AB toxin destroys cytoskeletal structure of enterocytes, causing pseudomembranous colitis.
- gram positive rod
- weakly acid fast and aerobic
- causes pulmonary infection in immunocompromised patients
What does primary infection with Mycobacterium tuberculosis lead to
- Ghon complex (hilar nodes/ ghon focus)
- healing by fibrosis
- progressive lung disease
- Miliary tuberculosis
- Preallergic lymphatic or hematogenous dissemination -> dormant tubercle bacilli in several organs -> reactivation in adult life (CNS, Pott's, lymphadenitis, renal, GI)
What would you like to do?
Home > Flashcards > Print Preview