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2012-09-22 16:22:43
Infectious diseases

Dr. Schiff
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  1. M-protein
    major type specific protein associated with virulent strep and has a carboxy terminus anchored in the cytoplasmic membrane and an amino terminus that extends through the cell wall about the cell surface
  2. lipoteichoic acid + F-protein
    act as adhesins and interact with fibronectin on the surface of the host cell
  3. capsule
    contains hyaluronic acid and is the outermost layer that prevents strep phagocytosis by forming a physical barrier
  4. Spes - Streptococcal pyogenic exotoxins
    formerly known as “erythrogenic toxins”; heat-labile exotoxins that act as superantigens and interact with T cells and macrophages to produce rashi, shock and organ failure
  5. Steptolysin S
    oxygen-stable, cell bound, nonimmunogenic; produced in serum; stimulates release of lysosomal contents after phagocytosis; responsible for beta-hemolysis observed on blood agar
  6. Streptolysin O
    oxygen-labile, immunogenic compound that is irreversibly inhibited by skin cholesterols and cross-reacts with similar oxygen labile toxins
  7. streptokinases
    mediate cleavage of plasminogen to release plasmin which then cleaves fibrin and fibrinogen resulting in lysis of fibrin
  8. Deoxyribosenucleases
    enzymes that depolymerize free DNA present in pus reducing the viscosity of abscess material and facilitating spread of infection
  9. C5a
    complement component that mediates inflammation via recruitment and activation of phagocytic cells
  10. Hyaluronidase
    capable of breaking down an acidic compound (hyalruronic acid) that is responsible for cellular integrity; “spreading factor”
  11. pharyngitis
    "Strep Throat”, person-person transmission via droplets; rapid onset, fever, sore throat, erythematous posterior pharynx and exudate
  12. Scarlet Fever
    complication of streptococcal pharyngitis where the enfecting strep strain undergoes lysogeny via temperate bacteriophage to produce a pyrogenic exotoxin
  13. Pyoderma (Impetigo)
    an infective vesicular/pustular epidermal disease; characterized by formation of vesicles that lead to pustules that rupture and form crusts
  14. erysipelas
    skin infection that is known for the “butterfly-wing” rash and is characterized by erythema/inflammation, lymphadenopathy and leukocytosis
  15. Ludwig's Angina
    a form of cellulitis in the region of the submaxillary gland
  16. Necrotizing fasciitis
    • "streptococcal gangrene” by “flesh eating bacteria” that occurs deep in the subcutaneous tissue resulting in
    • destruction of muscle and fat tissue
  17. Strep TSS
    bacteremic immunocompromised patients susceptible to the effects of the pyrogenic exotoxin (SpeA); similar to TSS by staph
  18. Strawberry Tongue
    raw, red lingual surface observed in scarlet fever
  19. Pastia's Lines
    pink or red transverse lines at the bend of the elbow that blanch on application of pressure; in patients with scarlet fever
  20. Rheumatic fecer
    S. pyogenes disease may result in a nonsuppurative complication charactereized by arthralgias and myorcardial inflammation; associated with pharyngeal infections but not cutaneous infections
  21. Quinsy
    peritonsillar exudates of streptococcal pharyngitis
  22. Glomerulonephritis
    complication of disease with S. pyogenes characterized by renal glomerular inflammation, hematuria, proteinurea, and HTN