- 1. Glucose comes thru portal vein --> liver
- 2. In liver, glucose --> G6P; high insulin levels
- 3. Glycogen synthase is activated, while glycogen phosphorylase is deactivated
- 4. Glycogenesis, glycolysis, TCA, and ETC will occur.
Glycogenesis - PP1 activates glycogen synthase and deactivates glycogen phosphorylase; cAMP destroyed.
Glycolysis: Insulin activates glucokinase & pyruvate kinase
PPP: Insulin stimulates G6PD
TCA cycle: Insulin activates PDH via PDH phosphatase
Fats: synthesis of FAs and TAGs