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The 4 main components of collagen are: (Ordered by highest % to lowest)
- 1) Glycine GLY 2) Proline PRO
- 3) 4-Hydroxyproline HYP 4) 5-hyrodxylisine HYL
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Two main sequences of collagen
GLY- pro -- y
GLY-x-HYP
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What causes twisted helical structure in collagen
High% of proline
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What does elastin lack?
Secondary structure
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What is the abnormally high concentration of AA in urine?
aminoaciduria
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How many AA are there in humans?
20
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Which do PKU people lack?
phenylalanine hydroxylase
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What is a hapten?
small molecule to which an anitbody can bind
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How many AA in heavy/light chains?
440/220
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What bonds hold together polpeptide chains?
Disulfide
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Which Ig has the highest concentration in plasma?
IgG
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Which Ig functions in mucosal secretion?
IgA
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Which Ig plays a major role in allergies?
IgE
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Which Ig is the 1st antibody produced in response to foreign antigen?
IgM
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Which Ig can pass through the placenta?
igG
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Myoglobin is a ____ with __ heme group(s)
monomer, uno
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Hemoglobin is a ___ with __ heme groups
teramer, 4
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What are the major anions in cell fluid?
Phosphate, bicarbonate
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What is the major cation is cell fluid?
k+
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What is the major cation in blood plasma?
NA+
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What is the major anion in blood plasma?
CL-, HCO3-
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What is an invariate residue?
An AA that does not change position (plays important role)
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What is homologous?
2 sequences that are highly alignable
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What is a substitution of one amino acid for another that is of similarpolarity (ex. Alanine for Valine or Apartic Acid for Glutamic Acid).
Conservative subs.
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What is a substitution of one amino acid for another that is of dissimilar polarity or geometric configuration?
non-conservative
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