Pcol more cards for exam 1

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what is atropine?

a direct-acting muscarinic antagonist
what effect does ACh produce on the CNS?

none ; ACh doesn't cross the BBB
what is bathanechol?

a direct-acting muscarinic agonist
what is pilocarpine?

a direct-acting muscarinic agonist
name 3 important reversible indirect-acting cholinesterase inhibitors
- physostigmine
- neostigmine
- pyridostigmine
name 4 important direct-acting muscarinic agonists
- ACh
- bethanechol
- pilocarpine
- muscarine
what are some adverse CNS effects seen with pilocarpine/muscarine
- irritability
- restlessness
- ataxia
- hallucinations
- drowsiness/sedation
what is the treatment for a parasympathomimetic overdose?

give a muscarinic antagonist like atropine
what are the peripheral effects of cholinesterase inhibitors?
- Salivation
- Lacrimation
- Urination
- Defication
- GI pain
- Emesis
- Sweating -- (SLUDGES)
T/F - physostigmine crosses the BBB

true
T/F -neostigmine crosses the BBB

false
What does pralidoxime (2-PAM) do?

it complexes with organophosphates and removes it from cholinesterase - used to treat organophosphate poisoning
what are 3 reversible cholinesterase inhibitors used in the treatment and diagnosis of Myasthenia gravis?
- pyridostigmine(tx)
- ambenonium(tx)
- edrophonium(dx)
what cholinesterase inhibitor is often used in the treatment of Alzheimer's?

Donepezil(Aricept)
what is malathion and what is it commonly used for?

organophosphate used as an insecticide
what drug is a prophylaxis treatment for organophosphate exposure and how does it work?

pyridostigmine ; ties up organophosphate binding sites on receptors

Author:	Anonymous
ID:	173639
Card Set:	Pcol more cards for exam 1
Updated:	2012-09-26T19:55:14Z
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Description:	Pcol more cards for exam 1
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