Pcol more cards for exam 1

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  1. what is atropine?
    a direct-acting muscarinic antagonist
  2. what effect does ACh produce on the CNS?
    none ; ACh doesn't cross the BBB
  3. what is bathanechol?
    a direct-acting muscarinic agonist
  4. what is pilocarpine?
    a direct-acting muscarinic agonist
  5. name 3 important reversible indirect-acting cholinesterase inhibitors
    • physostigmine
    • neostigmine
    • pyridostigmine
  6. name 4 important direct-acting muscarinic agonists
    • ACh
    • bethanechol
    • pilocarpine
    • muscarine
  7. what are some adverse CNS effects seen with pilocarpine/muscarine
    • irritability
    • restlessness
    • ataxia
    • hallucinations
    • drowsiness/sedation
  8. what is the treatment for a parasympathomimetic overdose?
    give a muscarinic antagonist like atropine
  9. what are the peripheral effects of cholinesterase inhibitors?
    • Salivation
    • Lacrimation
    • Urination
    • Defication
    • GI pain
    • Emesis
    • Sweating -- (SLUDGES)
  10. T/F - physostigmine crosses the BBB
    true
  11. T/F -neostigmine crosses the BBB
    false
  12. What does pralidoxime (2-PAM) do?
    it complexes with organophosphates and removes it from cholinesterase - used to treat organophosphate poisoning
  13. what are 3 reversible cholinesterase inhibitors used in the treatment and diagnosis of Myasthenia gravis?
    • pyridostigmine(tx)
    • ambenonium(tx)
    • edrophonium(dx)
  14. what cholinesterase inhibitor is often used in the treatment of Alzheimer's?
    Donepezil(Aricept)
  15. what is malathion and what is it commonly used for?
    organophosphate used as an insecticide
  16. what drug is a prophylaxis treatment for organophosphate exposure and how does it work?
    pyridostigmine ; ties up organophosphate binding sites on receptors

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Author:
 Anonymous
ID:
 173639
Filename:
 Pcol more cards for exam 1
Updated:
2012-09-26 19:55:14
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more ffloyd pharmacology exam pcol ans sns pns
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