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what is atropine?
a direct-acting muscarinic antagonist
what effect does ACh produce on the CNS?
none ; ACh doesn't cross the BBB
what is bathanechol?
a direct-acting muscarinic agonist
what is pilocarpine?
a direct-acting muscarinic agonist
name 3 important reversible indirect-acting cholinesterase inhibitors
physostigmine
neostigmine
pyridostigmine
name 4 important direct-acting muscarinic agonists
ACh
bethanechol
pilocarpine
muscarine
what are some adverse CNS effects seen with pilocarpine/muscarine
irritability
restlessness
ataxia
hallucinations
drowsiness/sedation
what is the treatment for a parasympathomimetic overdose?
give a muscarinic antagonist like atropine
what are the peripheral effects of cholinesterase inhibitors?
Salivation
Lacrimation
Urination
Defication
GI pain
Emesis
Sweating -- (SLUDGES)
T/F - physostigmine crosses the BBB
True
False
true
T/F -neostigmine crosses the BBB
True
False
false
What does pralidoxime (2-PAM) do?
it complexes with organophosphates and removes it from cholinesterase - used to treat organophosphate poisoning
what are 3 reversible cholinesterase inhibitors used in the treatment and diagnosis of Myasthenia gravis?
pyridostigmine(tx)
ambenonium(tx)
edrophonium(dx)
what cholinesterase inhibitor is often used in the treatment of Alzheimer's?
Donepezil(Aricept)
what is malathion and what is it commonly used for?
organophosphate used as an insecticide
what drug is a prophylaxis treatment for organophosphate exposure and how does it work?
pyridostigmine ; ties up organophosphate binding sites on receptors
Author
Anonymous
ID
173639
Card Set
Pcol more cards for exam 1
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Pcol more cards for exam 1
Updated
9/26/2012, 7:55:14 PM
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