- The removal of the “oxy” at 2’-carbon uses an enzyme called Ribonucleotide Reductase
(which “reduces” the carbon-oxygen bond by adding hydrogens
- Ribonucleotide reductase uses an important cofactor –Thioredoxin
– which contributes two sulfhydril groups (SHs) to drive the reaction.
- Thioredoxin gets “recycled” (reduced back to 2 free –SH groups) by NADPH + H +