Alzhiermers Drugs

Card Set Information

Author:
krug0043
ID:
17414
Filename:
Alzhiermers Drugs
Updated:
2010-05-03 01:12:55
Tags:
CNS
Folders:

Description:
Pharmacology II
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  1. NSAID Use
    Prophylaxis -Long term use before symptoms arise may prevent or retard AD development.
  2. NSAID MOA
    Improves brain blood flow?
  3. Statins Use
    prophylaxis
  4. Statins MOA
    Reduces hypercholesterimia.
  5. Antihypertensive Drugs Use
    prophylaxis
  6. Antihypertensive Drugs MOA
    High bp in middle age correlates with increased AD incidence later.
  7. Tacrine Use
    For (minor) enhancement of neurotransmission and cognition in AD
  8. Tacrine MOA
    reversible cholinesterase inhibitor
  9. Donepezil MOA
    reversible cholinesterase inhibitor
  10. Rivastigmine MOA
    reversible cholinesterase inhibitor
  11. Glantamine MOA
    reversible cholinesterase inhibitor
  12. Memantine MOA
    reversible NMDAr antagonist
  13. Tacrine Use
    For (minor) enhancement of neurotransmission and cognition in AD
  14. Donepezil Use
    For (minor) enhancement of neurotransmission and cognition in AD.
  15. Rivastigmine Use
    For (minor) enhancement of neurotransmission and cognition in AD.
  16. Glantamine Use
    For (minor) enhancement of neurotransmission and cognition in AD.
  17. Mematine Use
    Additive benefit when used with reversible cholinesterase inhibitors.
  18. Tacrine Adverse Effects
    Cholinergic (SLUD)

    Major Direct Hepatic Toxicity
  19. Donepezil Adverse Effects
    Cholinergic (SLUD)

    No Direct Hepatic Toxicity

    Yes hepatotoxic drug interactions
  20. Rivastigmine Adverse Effects
    Cholinergic (SLUD)

    No Direct Hepatic Toxicity

    No hepatotoxic drug interactions
  21. Glantamine Adverse Effects
    Cholinergic (SLUD)

    No Direct Hepatic Toxicity

    Yes hepatotoxic drug interactions
  22. Tacrine Distinguishing Trait
    1st reversible choinesterase inhibitor.

    Not marketed anymore

    non-selective

    QID
  23. Donepezil Distinguishing Characteristics
    DOC for AD patients who are not on multidrug regimines.
  24. Rivastigmine Distinguishing Traits
    DOC for AD patients who ARE on multi-drug regimens.
  25. Glantamine
    Non selective.

    Potentiates nicotinic Ach response too.

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