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What are the primary cells HIV targets
- CD4-helper T cells
- Dendritic cells
- Natural Killer cells
How does HIV induce aptoptosis
HIV infected cells shed soluble ciral envelope gp120, which can induce apotptosis of uninfected T lymphocytes, neurons, monocytes through interaction on the cell surface receptors.
What are the receptor cells on the HIV and cell surface that interact
CD4 cell of the Helper T and gp120 on the HIV virus.
Once CD4 and gp 120 have fused, what happens
HIV virus is injected into the cytoplasm
What is special about the retrovirus HIV
It is converted into a double stranded DNA provirus by action of the viral reverse transcriptase
What happens to the immune system when infected with HIV
HIV attacks the immune system cells and destroys ability to fight infection. (lymphocytes, phagocytes, macrophages)
What body systems are affected by the HIV virus
- Lymph nodes
- Bone Marrow
At what point in the HIV process do the drug interactions work
Reverse transcriptase and Viral protease