S4M2 GI

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Author:
sweetlu
ID:
175781
Filename:
S4M2 GI
Updated:
2012-10-13 15:14:56
Tags:
S4M2 GI
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Description:
S4M2 GI
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  1. melena
    • black tarry stool from bleeding in UGI
    • **req at least 60 ml and 10-14 hours**
  2. gross section turns yellow after formalin fixation
    • intestinal carcinoid
    • SI>LI
  3. flushing face, HTN, diarrhea
    think carcinoid (NE tumor) secreting high levels of hormones like 5-HT
  4. MCC of cholangiocarcinoma
    liver fluke biliary infection
  5. exposure to vinyl chloride, arsenic or thorotrast
    Hempatic angiosarcoma
  6. grossly thickened gastric wall
    gastric lymphoma
  7. APC mutation seen in ashkenazi jews
    I1307K
  8. defect in MYH associated polyposis and what cn risk increased
    • DNA base-excision repair
    • duodenal cn risk increased
  9. most mutated gene in HNPCC
    • MSH2 and 1 (tumor suppressor genes)
    • "mismatch repair"

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