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- black tarry stool from bleeding in UGI
- **req at least 60 ml and 10-14 hours**
gross section turns yellow after formalin fixation
- intestinal carcinoid
flushing face, HTN, diarrhea
think carcinoid (NE tumor) secreting high levels of hormones like 5-HT
MCC of cholangiocarcinoma
liver fluke biliary infection
exposure to vinyl chloride, arsenic or thorotrast
grossly thickened gastric wall
APC mutation seen in ashkenazi jews
defect in MYH associated polyposis and what cn risk increased
- DNA base-excision repair
- duodenal cn risk increased
most mutated gene in HNPCC
- MSH2 and 1 (tumor suppressor genes)
- "mismatch repair"
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