Describe agouti mouse experiment
Genetic expressios? (6)
Young black female mice were fed normal diet/diet supplemented with B9,B12,methionine for 2 weeks prior to mating and throughout lactation --> gave birth to genetically identical offspring.
Conclusion: coat color is regulated by maternal diet; dietary methyl supp SILENCES agouti expression, resulting in darker colored animals.
Also, increased BP, more body fat, abnormal glucose tolerance, hyperphagia (esp with fat diet), impaired inflammatory response, reduced physical activity.