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Classification of Infarcts (2):
1.Transmural: more common / involve the entire thickness of myocardium
2. Subendocardial: less common / only involve inner portions of myocardium
Early Cellular Changes of Infarct (2):
- 1.Altered ion gradients
- 2. Drop in intracellular pH
Early Tissue Changes of Infarcts(4):
- 1. vascular permeability
- 2.Tissue edema (wavy fibers)
- 3.Neutrophil infiltration
- 4.Coagulation necrosis
Late Tissue Changes of Infarcts (2):
- 1.Resorption of dead tissue
- 2.Fibroblasts deposit new collagen matrix (fibrosis)
What are the Consequences of Transient Ischemia at the Tissue Level (5)?
- 1.Myocytes revert to glycolysis
- 2.LessATP is being produced
- 3.Morelactic acid being produced
- 4.Decrease in systolic contraction and diastolic relaxation
- 5.Accumulationof waste products stimulates pain receptors
What are the Consequences of Transient Ischemia at the Organ System Level (4)?
- 1.Pain triggers discharge of both sympathetic and parasympathetic systems
- 2.Increased sympathetics trigger increased heart and respiratory rates
- 3.Increased parasympathetics trigger nausea
- 4. Decreased systolic contraction and diastolic relaxation lead to pulmonary congestion
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