Pharm Nervous system

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tville01
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176485
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Pharm Nervous system
Updated:
2012-10-09 08:37:17
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Pharm Nervous system
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Pharm Nervous system
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  1. Sympathetic nervous system is aka
    • Fight or flight
    • &
    • Andrenergic system
  2. What are signs of SNS stimulation
    • dilated pupils
    • increased RR, HR, & P
    • decreased peristalsis
    • increased blood glucose
  3. What are the catecholamines for the SNS
    • norepinephrine
    • epinephrine
    • dopamine
  4. What do catecholamines/neurotransmitters for the SNS bind to
    adrenergic receptor
  5. Where are Alpha 1 adregeneric receptors located?
    post synaptic effector cells that stimulate the nerve
  6. Where are Alpha 2 adregeneric receptors located?
    pre-synaptic nerve terminals
  7. What do Alpha 2 adregeneric receptors control?
    release of the neurotranmitters(epinephrine & norepinephrine)
  8. What SNS effect will you get when the alpha receptors are stimualted
    • vasoconstriction & CNS stimulation
    • Increased BP
  9. Where are Beta 1 receptors located?
    heart and kidneys
  10. What occurs when Beta 1 receptors are stimulated
    • increased HR
    • increased heart contractility
    • increased renin secreations
  11. When when Beta 1 receptors are stimulated what is the positive intropic effect
    increased force of contraction
  12. When when Beta 1 receptors are stimulated what is the positive chronotropic effect
    Increased HR
  13. When when Beta 1 receptors are stimulated what is the positive dromotropic effect
    increased impulses through the AV node
  14. What occurs when Beta 2 receptors are stimulated
    • bronchdialtion
    • relaxation of smooth muscle in GI & GU
    • increased glycogenolysis
  15. Where are Beta 2 adrenergic receptors located
    smooth muscle fibers of bronchioles, arterioles, and visceral organs(lungs)
  16. What stimulates the dopamine receptors
    dopamine only
  17. What occurs when dopaminergic receptors are stimulated
    renal mesenteric, coronary, and cerebral arteries dialte

    Increase blood flow
  18. What are sympathomimetic drugs
    Drugs that mimic the effects of the SNS
  19. What is the action of mechanism of direct acting sympathomimetic drugs
    Bind directly to the receptor and cause a reaction
  20. What is the action of mechanism of indirect acting sympathomimetic drugs
    Cause neurotransmitters to be released from storage sites, they then bind to receptors and cause a response
  21. What is the action of mechanism of mixed acting sympathomimetic drugs
    They bind to receptors and cause the release of neurotranmitters to cause a reaction
  22. What are the indications for adrenergic drugs?
    Respiratory=Asthama & bronchitis

    Topical nasal decongestant

    Opthalmic=glaucoma & eye exam

    Cardio= vascoconstriction/Increase BP
  23. When using adrenergic drugs for asthma and bronchitis what receptor is effected and what occurs
    • Beta 2
    • bronchodilation
  24. What are some examples of adrenergic drugs for asthma or bronchitis
    • albuterol
    • ephedrine
    • epinephrine
    • salmeterol
  25. When using adrenergic drugs as a topical nasal decongestant what receptor is effected and what occurs
    • Alpha 1
    • vasoconstriction
  26. What is an example of an adrenergic drug used as a topical nasal decongestant
    phenylephrine
  27. When using adrenergic drugs for glaucoma or eye exams what receptor is effected and what occurs
    • Alpha 1
    • vasoconstriction
    • reduction in intraocular pressure
    • pupil dialtion
  28. What is an example of an adrenergic drug used as for glaucoma or eye exams
    • epinephrine
    • phenlyephrine
    • tetrahydrozline
  29. When using adrenergic drugs for the cardiovascular system(pressors) what receptor is effected and what occurs
    • Both Alpha & Beta
    • Vasoconstruction
    • Increases BP
    • Used to support cardio system during cardiac failure
  30. What are some examples of "pressors" and how are they given
    • doubtamine
    • dopamine
    • epinephrine
    • fenoldopam
    • norepinephrine
    • Given by IV or pump, not meds a pt. will be sent home on
  31. What are the only contraindications for adrenergic drugs
    • Known allergy
    • Severe hypertension

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