pharm II immunosuppressants

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  1. mechanism of calcineurin inhibitors?
    Inhibit calcineurin by suppressing IL-2
  2. primary use for calcineurin inhibitors?
    patients with hx of transplant
  3. action of cyclosporine?
    suppresses production of IL-2; inhibits B cells and cytotoxic T cells
  4. adverse effects of cyclosporine?
    • nephrotoxicity (up to 75% of patients)
    • hepatotoxicity, lymphoma
  5. cyclosporine usually used in combo with what other drug?
    glucocorticoids (e.g., Prednisone)
  6. fx of B lymphocytes?
    make antibodies
  7. fx of cytolytic T cells?
    attack and kill cells directly
  8. fx of helper T cells?
    promote proliferation of B cells
  9. sirolimus is used specificially for what?
    prevention of renal transplant rejection
  10. side fx of sirolimus?
    • increased cholesterol and triglycerides
    • increased risk of infection
    • increased risk of renal injury
  11. sirolimus given prophylactically for what?
    PCP (~1 year) and CMV (~3 mos)
  12. glucocorticoids (prednisone) therapeutic uses?
    used for flares of inflammatory diseases, eg asthma, chrons disease, ulcerative colitis, IBD
  13. long-term side fx of prednisone?
    • osteoporosis
    • in children: impaired growth
  14. cytotoxic drugs' mechanism of action?
    • suppresses immune response
    • kills B and T lymphocytes that are undergoing proliferation
  15. cytotoxic drugs' side fx?
    • bone marrow suppression
    • thrombocytopenia/neutropenia
  16. ? > ? / ? < ?
    • WBC > hgb / Hct < platelets
    • 3.5-11 > 120-175 / 31-53 < 140-450
  17. azathropine, cyclophosphamide, methotrexate, CellCept - what class?
    cytotoxic drugs

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pharm II immunosuppressants
2012-10-15 12:38:03

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