Pharmaco test 2

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cleas
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177094
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Pharmaco test 2
Updated:
2012-10-23 21:34:18
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pharmacology pharmaco dr culver nair uwsop
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drugs for hypertension, diuretics(BOOM! Nailed It)
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  1. Sympathomimetic agents/ Adrenergic agonists
    • Catacholamines
    • Alpha adrenergic agents
    • Mixed; direct/indirect/ CNS
    • Indirect
    • Beta adrenergic agent
  2. Catecholamine drugs
    • Epinephrine
    • Norepinephrine
    • Isoproterenol
    • Dopamine
    • Fenolodopam
    • Dobutamine
  3. Alpha adrenergic agents
    • Phenylephrine (prototype)
    • Oxymetazoline
    • Pseudoephedrine
    • Clonidine
  4. Mixed sympathomimetic agents
    • Ephedrine
    • Amphetamines
    • Phenylpropanolamine
  5. Indirect acting sympathomimetics
    • Cocaine
    • Tyramine
  6. Beta adrenergic agents
    • Metaproterenol
    • Albuterol
    • Terbutaline
    • Dobutamine
  7. Non selective alpha blockers
    • Phentolamine
    • Phenoxybenzamine
  8. Selective alpha 1 receptor blockers
    • Prazosin (prototype)
    • Tamsulosin (BPH)
  9. Selective alpha 2 receptor blockers
    Yohimbine
  10. Non selective beta blockers
    • Propranolol (prototype)
    • Timolol
  11. Selective beta 1 receptor blockers
    • Metoprolol (prototype)
    • Atenolol
  12. Beta blockers with Intrinsic Sympathomimetic Activity (ISA)
    • Pindolol (non selective beta 1 and 2)
    • Acebutolol (beta 1 selective)
  13. Thiazide Diuretics
    Hydrocholorothiazide
  14. High ceiling (loop) diuretics
    Furosemide
  15. Potassium Sparing Diuretics
    Spironolactone
  16. Centrally acting sympatholytics
    • Methyldopa
    • Clonidine
  17. Sympatholytics acting on adrenergic neurons
    • Guanethidine
    • Reserpine
  18. Ganglionic blocking agents
    Mecamylamine (only one available)
  19. Vasodilators
    • Hydralazine
    • Minoxidil
  20. Vasodilators for hypertensive emergency
    • Nitroprusside
    • Diazoxide
    • Fenoldopam
  21. Cardioactive calcium channel blockers (CCB)
    • Verapamil
    • Diltiazem
  22. Vasoactive calcium channel blockers (CCB)
    • Nifedipine
    • Amlodipine
  23. Angiotensin-Converting Enzyme Inhibitors (ACE I)
    • Captopril (prototype)
    • Enalapril
    • Lisinopril
  24. Angiotensin II Receptor Blockers (ARBs)
    • Losartan
    • Irbesartan
  25. Renin Inhibitors
    Aliskiren (only one)
  26. Aldosterone antagonists
    • Spironolactone
    • Eplerenone (preferred due to fewer AE on sex hormones)
  27. Uses of epinephrine
    • allergic reactions
    • COPD
    • asthma
    • mydriasis
    • reduce intraocular pressure
    • cardiac arrest
  28. adverse effects of epinephrine
    • hypertension
    • tachycardia
    • ventricular arrythmia
    • tissue damage/ necrosis at injection site
    • CNS effects
    • hyperglycemia
  29. uses for norepinepherine
    acute hypotensive emergencies
  30. uses for isoproterenol
    • bronchodilator
    • cardiac stimulant (shock MI)
  31. A/E for Isoproterenol
    • tachycardia
    • hypotension
    • palpatations, anxiety, H/A, angina
  32. uses for dopamine
    • shock
    • heart failure
    • acute renal failure
  33. A/E for dopamine
    • tachycardia, arrythmias
    • hypertension
    • N/V
  34. uses for alpha-1 selective agents
    • acute hypotensive conditions
    • reduction of regional blood flow
    • ophthalmic uses, mydriasis, glaucoma, allergic hyperemia
  35. uses for alpha-2 selective agent
    • antihypertensive (CNS)
    • reduce symptoms of withdrawl
    • analgesia
    • reduce intraocular pressure
  36. use for indirect sympathomimetic drugs
    • bronchodilator
    • cardiovascular uses
    • mydriasis
    • decongestant
  37. use of beta-2 selective agents
    • bronchodilator
    • delay delivery of premature labor
  38. uses of beta-1 selective agents
    cardiac stimulation
  39. uses for non-selective alpha blockers
    • prevent ischemic necrosis
    • limited use to lower BP
    • Dx and Tx of pheochromocytoma
    • peripheral vascular diseases
  40. uses for selective alpha-1 inhibitors
    • management of essential hypertension
    • prevention of urinary retention in BPH
  41. A/E for alpha blockers
    • postural hypotension
    • reflex tachycardia
    • nasal congestion
    • miosis
    • N/V, GI pain
    • Priapism
  42. uses of beta receptor blockers
    • Tx of cardiac arrhythmias
    • Tx of coronary insufficiency and angina pectoris
    • Tx of thyrotoxicosis
    • managment of hypertension
    • CNS indications
    • Tx of glaucoma
    • Tx of CHF
  43. A/E of beta receptor blockers
    • caution with function compromised
    • bronchospasm
    • intensify hypoglycemia
    • masks¬† tachycardia
    • CNS effects
    • intensify symptoms of PVD
    • decline in HDL/LDL ratio
  44. abrupt discontinuation of beta blockers leads to what
    • rebound HTN
    • increased risk of IHD
  45. what are the sites of BP regulation
    • arterioles (resistance)
    • venules (capacitance)
    • heart (pump output)
    • kidneys (volume control)
    • and ultimately the brain
  46. three basic processes of the nephron
    • glomerular ultrafiltration
    • tubular reabsorption
    • active tubular secretion
  47. carbonic anhydrase inhibitors
    acetazolamide
  48. uses of the carbonic anhydrase inhibitors
    • Glaucoma
    • high altitude sickness
    • alkalinization
    • metabolic alkalosis
  49. what are the 3 compensatory mechanisms for hydralazine (is poster child)
    • reflex tachycardia
    • increased renin
    • na and water retention
  50. what are the classes of diuretics used in hypertension
    • thiazides
    • loop (high ceiling)
    • potassium sparing
  51. sites of action for sympatholytics
    • brain
    • adrenergic receptors
    • adrenergic receptors
    • autonomic ganglia
  52. some cardioactive drugs?
    • verapamil
    • diltiazem
  53. vasoactive agents
    • nifedipine
    • amlodipine

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