UMMC Pharm test2 Cholinergic drugs

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sullydog101
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177208
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UMMC Pharm test2 Cholinergic drugs
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2012-10-12 16:46:11
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UMMC Pharm test2 Cholinergic drugs
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UMMC Pharm test2 Cholinergic drugs
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  1. Acetylcholine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Mixed receptor Agonist (direct acting)
    • Receptors: Nn, Nm, M1-5
    • T.U.: Opthalmic solution for surgery (M3)
    • Other: Quaternary Amine, Short duration
  2. Nicotine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Nicotinic agonist (direct acting)
    • Receptors: Nn, Nm
    • T.U.: treat nicotine dependence, insecticide
    • Other: Tertiary amine, metabolized in liver
  3. Varenicline (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Nicotinic partial agonist
    • Receptors: α4β2
    • T.U.: Treat nicotine dependence
    • Other: crosses BBB, decreases effect of nicotine
  4. Muscarine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Agonist (Direct acting)
    • Receptors: M1-5
    • T.U.: N/A
    • Other: quaternary amine
  5. Pilocarpine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic agonist (Direct acting)
    • Receptors: M1-5
    • T.U.: Wide angle glaucoma, Xerostomia
    • Other: Tertiary amine
  6. Methacholine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Agonist (Direct acting)
    • Receptors: M1-5 (weak Nn)
    • T.U.: Diagnose bronchial hyperractivity (s.c.)
    • Other: slower metabolism by AChE
  7. Carbachol (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Mixed receptor Agonist (direct acting)
    • Receptors: Nn, M1-5
    • T.U.: Miosis for surgery, Wide angle Glaucoma
    • Other: Long duration of action
  8. Bethanecol (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Agonist (Direct acting)
    • Receptors: M1-5
    • T.U.: GI atony, Urinary retention
    • Other: Long duration, Contraindicated with obstruction, Orally effective
  9. Edrophonium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Reversible Anticholinesterase (Indirect acting)
    • Receptors: All ACh receptors
    • T.U.: Diagnose Myasthenia Gravis, evaluate myasthenic/cholinergic crisis, Paroxysmal atrial tachycardia
    • Other: Quaternary amine, short duration ~10min
  10. Neostigmine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Reversible Anticholinesterase (Indirect acting)
    • Receptors: All ACh receptors
    • T.U.: Myasthenia Gravis, Glaucoma, GI/U atony, Reversal NMJ block
    • Other: Quaternary amine, long duration (4-6hr)
  11. Pyridostigmine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Reversible Anticholinesterase (Indirect acting)
    • Receptors: All Ach receptors
    • T.U.: Myasthenia Gravis, Nerve Gas Prophylaxis
    • Other: Quaternary amine, 6-8 hrs
  12. Physostigmine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Reversible Anticholinesterase (Indirect acting)
    • Receptors: All Ach receptors
    • T.U.: Glaucoma, Muscarinic antagonist OD (severe),
    • Other: Tertiary amine
  13. Donepezil (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Reversible Anticholinesterase (Indirect acting)
    • Receptors: All Ach receptors
    • T.U.: Alzheimer disease
    • Other: tertiary amine, Does NOT prevent degeneration
  14. Echothiophate (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Irreversible Anticholinesterase (Indirect acting) Organophosphate
    • Receptors: Binds to AChE/BuChE
    • T.U.: Glaucoma
    • Other: Quaternary Amine
  15. Methylparathion (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Irreversible Anticholinesterase (Indirect acting) Organophosphate
    • Receptors: Binds to AChE/BuChE
    • T.U.: Insecticide
    • Other: activated in liver, fairly safe
  16. Malathion (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Irreversible Anticholinesterase (Indirect acting) Organophosphate
    • Receptors: Binds to AChE/BuChE
    • T.U.: Insecticide
    • Other: activated in liver, fairly safe
  17. Sarin (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Irreversible Anticholinesterase (Indirect acting) Organophosphate
    • Receptors: Binds to AChE/BuChE
    • T.U.: Nerve Gas
    • Other: Treat exposure with 2-PAM
  18. Soman (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Irreversible Anticholinesterase (Indirect acting) Organophosphate
    • Receptors: Binds to AChE/BuChE
    • T.U.: Nerve Gas
    • Other: Treat exposure with 2-PAM
  19. Pralidoxime (2-PAM) (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Cholinesterase regenerator
    • Receptors: Binds to AChE/BuChE
    • T.U.: Nerve gas exposure
    • Other: Highly nucleophilic, have to treat before “aging” occurs
  20. Sildenafil (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Parasympathomimetic (Indirect)
    • Receptors: cGMP PDE
    • T.U.: ED (Viagra), Pulmonary hypertension (Revatio)
    • Other: ~1hr onset, 4-5hr duration
  21. Tadalafil (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Parasympathomimetic (Indirect)
    • Receptors: cGMP PDE
    • T.U.: ED
    • Other: 1-2hr Onset, 36 hr duration “the weekender”
  22. Vardenafil (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Parasympathomimetic (Indirect)
    • Receptors: cGMP PDE
    • T.U.: ED
    • Other: ~1hr onset, 4-5hr duration
  23. Trimethaphan (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Nicotinic Receptor Antagonist (Ganglionic Blocker)
    • Receptors: Nn (α3β4)
    • T.U.: Rapidly decrease BP to decrease blood loss during surgery/dissecting AA
    • Other: Acute IV treatment only
  24. Mecamylamine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Nicotinic Receptor Antagonist (Ganglionic Blocker)
    • Receptors: Nn (α3β4)
    • T.U.: Tourette’s Syndrome
    • Other: Oral
  25. Tubocurarine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Nm antagonist
    • T.U.: Adjunct to general anesthesia, surgery, artificial respiration, intubation, seizure control
    • Other: IV only, No CNS, slow onset ~4-6 min, Long duration ~80-120min, histamine release
  26. Pancuronium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Nm antagonist
    • T.U.: Adjunct to general anesthesia, surgery, artificial respiration, intubation, seizure control
    • Other: slow onset ~4-6 min, Long duration ~120-180min, “vagolytic” action
  27. Cisatracurium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Nm antagonist
    • T.U.: Brief procedures
    • Other: Onset ~2-4 mins, Duration ~ 30-40min, spontaneous hydrolysis
  28. Mivacurium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Nm antagonist
    • T.U.: Aid tracheal intubation
    • Other: Onset ~ 2-4min Duration ~ 12-18min, Inactivated by hydrolysis
  29. Rocuronium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Nm antagonist
    • T.U.: Rapid tracheal intubation
    • Other: 1-2min onset, 30-40min duration
  30. Succinylcholine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker (depolarizing blockade)
    • Receptors: Nm agonist
    • T.U.: Rapid paralysis
    • Other: onset 1-2min, 5 min duration, Metabolized by BuChE, not AchE
  31. Dantroline (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Skeletal Muscle Relaxant
    • Receptors: Sarcoplasmic Reticulum Ca^2+ channels
    • T.U.: Treatment of malignant hyperthermia brought about by anesthetics
    • Other: Blocks Ca^2+ release from sarcoplasmic reticulum
  32. Botulism Toxin A (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Neuromuscular Blocker
    • Receptors: Cholinergic Nerve Terminals, then L chain targets SNARE proteins
    • T.U.: Skeletal muscle disorders, Skin disorders, Esophagus/LES spasms
    • Other: Duration is variable (Nm upregulation, antibodies, nerve sprouting), no response in 2-5% patients
  33. Propantheline (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Diarrhea
    • Other: quaternary amine, Blocks receptors on GI muscle
  34. Ipratropium (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Asthma, COPD
    • Other: Inhaled
  35. Atropine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Cholinergic antagonist OD, mydriasis, cycloplegia
    • Other: tertiary amine (CNS effects)
  36. Scopolamine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Motion Sickness
    • Other: significant sedation, tertiary amine
  37. Tolterodine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M3
    • T.U.: Overactive bladder, incontinence
    • Other: M3 selective so less side effects, tertiary amine
  38. Tropicamide (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Brief mydriasis, cycloplegia
    • Other: 4-6hr duration, tertiary amine
  39. Benzotropine (Class, Receptors, Therapeutic Use, Other Comments)
    • Class: Muscarinic Receptor Antagonist
    • Receptors: M1-5
    • T.U.: Parkinsons disease
    • Other: tertiary amine, adjunct to L-DOPA therapy

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