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What are implications of high anion gap?
- Strongly suggests:
- = lactic acidosis (lactate)
- = ketoacidosis (BOH butyrate)
- = renal failure (sulfates, phosphates)
- = ingestion of certain poisons - salicylates (produce excess acid metabolites)
What is anion gap if HCO3- decreased and Cl- increased?
- Normal range = 5 - 11 mEq/L
- = gut (laxative abuse)
- = kidney disorders
Anion Gap formula
(Be able to calculate)
Anion Gap = [Na+] - [Cl-] + [HCO3-]
- high osmolol gap = solutes present in plasma that are not normally there
- strongly suggests methanol or ethylene glycol intoxication (esp. if greater than 25 mOsmol/kg)
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