What is the entire signal transduction process?
Immobile sperm enters the female reproductive tract which is BASIC and LOW CO2 conentration this cause a Na+ influx & H+ eflux spearact from the egg binds to its receptor in the sperm head which activates second messenger GTP to activate guanylate cyclase resulting in cGMP. This cause a K+ eflux, resulting in the hyperpolarization of the spermhead (because it is becoming slightly more negative) CREB binds to cAMP activating it as the spermhead tries to neutralize its pH with the Na+ & H+ influx & eflux. With the activation of cAMP transcription factors get going & Ca2+ influx is created, Na/K pumps are opened kicking out 2K's for every 3Na's. the ova then makes and releases ZP1,ZP2, & ZP3 proteins, when the ZP3 protein & receptor bind together carbohydrates come in and contaminate the membrane, preventing polyspermy, and Ca+/T-channels are activated which create a Ca+ influx (in the egg?)