Patho 3

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Author:
cgordon05
ID:
17805
Filename:
Patho 3
Updated:
2010-05-04 21:07:10
Tags:
endocrine glycemia
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Description:
endocrine glycemia
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  1. Role of counter-regulatory hormones - glucagon, cortisol, catecholamines.
    (p.12)
    • increased breakdown of TG --> FFA and glycerol in adipose tissue
    • mobilization of FFA
    • increase blood glucose
    • cortisol increases gluconeogenesis - increase blood glucose production
  2. What effect will NKH have on lipolysis when compared with DKA?
    (p.15)
    • NKH = no effect on lipolysis
    • DKA = increases lipolysis
    • decreased or no insulin --> decreased uptake of glucose by adipocytes and muscle cells
    • increased breakdown of TG --> FFA and glycerol in adipose tissue --> mobilization of FFA
  3. What alterations in serum osmolality would you expect in HHNK vs. DKA and why?
    (p.22-23)
    • serum osmolality in HHNK approximately 400 mmol/L
    • (320 mmol/L in DKA)
    • HHNK =
    • = dramatic volume loss
    • = dehydration
    • = decreased vascular volume
  4. Know the different cells that require glucose for insulin uptake.
    (p.12)
    • skeletal
    • cardiac
    • adipose
    • in absence of insulin, these are truly diabetic cells
  5. Which cell type is most dependent on glucose for energy?
    (p.13)
    • Neuron
    • - very little glycogen storage
    • - little TG storage
    • - big glucose demand
    • - absolute glucose dependency
  6. When would you expect to see an increase in VLDL synthesis by the liver? (p.15)
    increased mobilization of FAs to liver --> increased gluconeogenesis and synthesis of VLDLs --> circulation and accumulation of FAs in liver (droplet form)
  7. What effect would insulin deprivation have on circulating VLDLs?
    (p.15)
    circulation and accumulation of fatty acids in the liver

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