Bio Aging Midterm Discussion papers and Aging patterns.txt

The flashcards below were created by user rincrocci on FreezingBlue Flashcards.

  1. Istvan Szabo
    First to determine the Type III aging pattern, doing research on oak trees (theorized from Raymond Pearl)
  2. Alex Comfort
    Dog breeding studies: showed that lifespan increases in dog breeds with larger brain:body ratio
  3. Rajindal Sohal
    Showed that increase in metabolic activity, along with an increase in temperature causes increase in mortality rates in houseflies
  4. Weindruch & Walford
    • showed that reduced calorie diet in mice showed:
    • 1. Increase in % survival
    • 2. Decrease in body mass
    • 3. decrease in TUMOR mortality
  5. James Carey et. al
    • Carried out LARGEST study with MedFlys: showing NOT exhibiting Gompertz pattern.
    • Flies had higher survival rates as age INCREASED
  6. Muggleton & Danielli
    discovered that immortal amoebas could be transformed to 'spanned' amoebas with NUTRIENT DEPRIVATION, even briefly
  7. Thomas and Dennis Nyberg
    • Showed Vitamin E supplementation for paramecium cells increases lifespan
    • Data showed a Type I Gompertzian slope curve
  8. Hamilton and Mestler
    • Showed castrated males vs intact had more higher life expectancy.
    • Also showed mentally retarded males exhibited hyperbolic pattern of age-related mortality increase
  9. Westendorp and Kirkwood
    • Looked at British aristocracy
    • showed that women age of first child birth and # of children correlate with longevity of females
    • Longer you wait until first child, and if only have 1 child: show longest longevity
  10. Massie, et al. (p601)
    • Using Drosophila melanogaster, show the increase in Vitamin A consumption is correlated to increase in longevity
    • Too much Vit A can be detrimental, however, causing a decrease in longevity
  11. Thomas dissertation related to redundancy and damage rate:
    • gene redundancy R: Determines how RAPID mortality rate Increases
    • redundancy may improve cell survivorship by reducing rate of loss of genetic info
    • small damage rate u (mew) and large redundancy = increase in survival
  12. Gompertz pattern
    • qx= qo (e)a(x)^n with N=1
    • Type I:
    • Linear curve on a semi-logarithmic mortality plot
    • Concave slope on double log plot
    • delta ln qx is POSITIVE and CONSTANT, so doubledelta q is ZERO (inverse Gomp w/type III shows neg delta lnqx)
    • Declining life expectancy with age
    • Constant MRDT with age
  13. Hyperbolic Pattern
    • qx=qo(e)a(x)^n
    • Type I:
    • Mortality INCREASES at accelerating rate
    • ConCAVE slope for semi and double log plot
    • delta lnqx is POSITIVE and INCREASING
    • Declining life-expectancy with age
    • Declining MRDT with age
  14. Weibull Pattern
    • qx=qo(x+1)^n with n > 0
    • ConVEX slope on semi-log plot
    • Linear on double log plot
    • delta lnqx Positive and DECREASING, double delta lnq is NEGATIVE
    • Declining life-expectancy with age
    • Increasing mortality rate doubling time w/age
  15. Logistic Pattern
    • lx = 1-(1-(1-u)^x)^R
    • Type I:
    • Slowest rate of senescence
    • Convex slope on semi-logarithmic (and double) mortality plot
    • Declining life expectancy with age
    • Increasing MRDT with age
    • ONLY with NO upper limit to Maximum lifespans
  16. Kapitanov and Aksenov
    • In stationary phase, immortal bacteria (Prokaryotes) exhibited REDUCED viability & INCREASED mortality
    • Followed Gompertz pattern: decrease in life expectancy with age
    • bacteria termed immortal b/c although they have rate of aging, they can sustain damage as long as their growth rates are high
  17. Type I vs II vs III
    • type I: Prob of death (qx) continuously INCREASING, with Life expectancy (ex) going DOWN
    • type II: qx and ex stay SAME
    • type III: probability of death (qx) DECREASES
  18. dx
    • # of prop. of ppl dying from age x to x+t
    • dx=lx - l(x+t)
  19. qx (probability of death)
  20. Lx
    • avg # of prop. of ppl surviving from age x to x+t
    • Lx= (lx + l(x+t))/2
  21. Tx
    • Total # of organism-age-intervals in lifetable
    • Tx=sum of Lx (Lx + L(x+t) + L(x+2t)...)
  22. ex (life expectancy)
    ex = (Tx)(t) / (lx)
  23. lx
    # of prop. of ppl surviving at age x
  24. x
    age interval
  25. t
    time interval b/w survival measurements
Card Set:
Bio Aging Midterm Discussion papers and Aging patterns.txt
2012-10-18 18:12:39
bio aging midterm disc articles patterns

aging patterns and discussion articles
Show Answers: