Amino Acid Properties

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Author:
goofnaggle
ID:
178194
Filename:
Amino Acid Properties
Updated:
2012-10-18 16:28:31
Tags:
aa amino acids
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Description:
Hydrophobic vs Hydrophilic, Properties, pKr and function
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  1. Ala
    (R, Hydro-, pI)
    • non-polar, aliphatic
    • hydrophobic
    • 6.01

    • -substitute with Ser, and other small aa
    • -boring, found in non-critical positions
    • -non-reactive
  2. Gly
    (R, Hydro-, pI)
    • non-polar, aliphatic
    • hydrophilic
    • pI = 5.97

    • -generally does not substitute; can sub with other small aa
    • -lots of conformational flexibility; reside in tight turns
  3. Pro
    (R, hydro-, pI)
    • non-polar, aliphatic
    • hydrophilic
    • pI = 6.48

    • -doesn't substitute well but will for other small aa
    • -structurally found in tight turns, also introduce kinks in a-helix
    • -usually found on surface
    • -non-reactive; bind to surfaces containing aromatics
  4. Val
    (R, hydro-, R)
    • non-polar, aliphatic
    • hydrophobic
    • pI= 5.97

    • -substitutes with other nonpolar aliphatics (I, M, L)
    • -bulky, NOT in a-helices; primarily in b-sheets
    • -non-reactive; lipid binding/recgognition
  5. Leu
    (R, hydro, pI)
    • non-polar, aliphatic
    • hydrophobic
    • pI= 5.98

    • -substitutes with other non-polar aliphatics (I, V, M)
    • -generally in a-helices
    • -non reactive; lipid binding/recognition
  6. Ile
    (R, hydro, pI)
    • nonpolar, aliphatic
    • hydrophobic
    • pI= 6.02

    • -sub with other aliphatics (L,M,V)
    • -bulky, no a-helix found in b-sheets
    • -non-reactive; lipid binding/recognition
  7. Met
    (R, hydro, pI)
    • nonpolar, aliphatic
    • hydrophobic
    • pI =  5.74

    • -sub with hydrophobic aa (I,V,L)
    • -buried in hydrophobic core
    • -limited function; metal binding
  8. Phe
    • aromatic
    • hydrophobic
    • pI = 5.48

    • -sub with Trp and Tyr especially
    • -buried in core; stacks with other aromatics
    • -non-reactive; lipid binding/recognition; aromatic stacking
  9. Tyr
    • aromatic
    • hydrophilic
    • pI = 5.66
    • pKr =10

    • -sub with PHE, Trp, His
    • -partially hydrophobic... buried in core; 
    • -stacking with aromatic; interactive with non-proteins
  10. Trp
    • aromatic
    • hydrophobic
    • pI = 5.9

    • -sub with Tyr, Phe
    • -buried in core
    • -non-reactive; stacking with aromatics
  11. Ser
    • polar, uncharged
    • hydrophilic
    • pI = 5.7

    • -sub with Ala, THR, Asn or other small or polar aa
    • -interior/exterior; common in tight-turns
    • -hydrogen bonds
  12. Thr
    • polar, uncharged
    • hydrophilic
    • pI = 5.9

    • -sub with Ser or other small or polar aa
    • -interior/exterior protein; bulky; unable to a-helix, found in b-sheets
    • -hydrogen bonds with polars
  13. Cys
    • polar, uncharged
    • hydrophobic
    • pI = 5.1
    • pKr = 8

    • -does not generally sub; will with other small aa (Ala)
    • -disulphide bonds to stablize structure
    • -metal binding
  14. Asn
    • polar, uncharged
    • hydrophilic
    • pI = 5.4

    • -sub with Asp, and other polar aa (Ser, His)
    • -surface
    • -similar role to D, polar interactions
  15. Gln
    • polar, uncharged
    • hydrophilic
    • pI = 6

    • -sub with Glu or other polar AA
    • -surface
    • -polar interactions
  16. Lys
    • Positively charged (basic)
    • hydrophilic
    • pI = 10
    • pKr  = 10-11

    • - sub with ARG may tolerate other polar (E,Q)
    • - is amphipathic (one end is buried, other is surface); generally surface
    • -create salt bridge with D, hydrogen bonds
  17. His
    • positively charged (basic)
    • hydrophilic
    • pI = 8
    • pKr = 6

    • -does not sub well... occasional (Y,N,)
    • -flexible (change from + to 0 easily); internal/external
    • -metal binding (C)
  18. Arg
    • positively charged (basic)
    • hydrophilic
    • pI = 10-11
    • pKr = 12

    • - sub with LYS, but tolerate other polar (Q)
    • - amphipathic, but generally external
    • - salt bridges with D, hydrogen bonds with polars
  19. Asp
    • negatively charged (acid)
    • hydrophilic
    • pI = 3
    • pKr = 3-4

    • - sub with GLN, ASn
    • - surface; salt-bridge
    • - hydrogen bond with polars
  20. Glu
    • negatively charged (acidic)
    • hydrophilic
    • pI = 3
    • pKr = 4

    • - sub with ASP, GLn
    • - surface; salt-bridge
    • - hydrogen bond with polars

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