pharm exam 2

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Author:
jakeg
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178283
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pharm exam 2
Updated:
2012-10-19 23:00:18
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cardio1
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pp1 for exam 2 review
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  1. Catecholamines
    Drugs
    • –Epinephrine (Adrenalin)
    • –Norepinephrine (Levophed)
    • –Isoproterenolol (Isuprel)
    • –Dopamine
    • –Dobutamine (Dobutrex)
    • cannot be given orally
    • (broken down by maoi & COMT)
    • do not cross BB barrier
  2. Epinephrine
    • Apha1 agonist-vasoconstriction, Increases blood pressure, Delay absorption of local anesthetics, Control superficial bleeding, Mydriasis for eye exams, Shock and anaphylaxis
    • Alpha 2 agonist-
    • Beta 1 agonist- Overcome AV heat block, Restore cardiac function in cardiac arrest and shock
    • Beta 2 agonist- Bronchodilation to treat, asthma and anaphylaxis
  3. Epinephrine- Adverse reactions
    • Hypertension, Necrosis, Angina, Dysrhythmias, Hyperglycemia
    • Extravasation=necrosis
  4. Epinephrine- drug interactions
    • MAOI (>level), TCA (inhibits reuptake)
    • Alpha Blockers, Beta Blockers: <levels
  5. Norepinephrine
    • •Similar effects as epinephrine
    • •Used primarily to treat hypotension and cardiac arrest
    • •Does not affect beta 2 receptors
    • •Monitor BP
    • •Avoid extravasation
    • no B2/ cant use to treat asthma¬†
  6. Isoproterenol
    • •Affect only beta 1 and beta 2 receptors
    • –Used to treat shock and cardiac arrest
    • –Asthma¬†
  7. Isoproterenol ADRs
    Adverse effects –Tachycardia –Angina –Hyperglycemia
  8. Isoproterenol-Drug interactions
    MAOI –TCA –Beta blockers
  9. Dopamine
    • •Activate alpha 1, beta 1 and dopamine receptors
    • –Used to treat shock- highest dose
    • –Heart failure- increased dose
    • –Renal failure- low dose
    • •Actions depend on dose
  10. Dopamine ADR
    • Tachycardia
    • –Angina
    • –Dysrhythmias
    • –Necrosis
  11. Dopamine- drug interactions
    •MOAI and TCA
  12. Dobutamine
    • Activates beta 1 receptors
    • •Used to treat heart failure (in ICU)
  13. Dobutamine- ADR
    Tachycardia Use with caution in patients with hyperthyroidism, HTN And angina
  14. Dobutamine- drug interactions
    MAOI and TCA
  15. Non-catecholamine- Phenylephrine (Neosynephrine) (& ADR)
    • –nasal spray
    • -Activate alpha 1 receptors
    • –Used to increase blood pressure, reduce nasal congestion, and mydriasis for eye exams
    • –ADR: necrosis due to extravasation
  16. Non-catecholamine-Terbutaline (Brethine)- no real use in cardiac
    • –Activates beta 2 receptors
    • –Used to treat asthma and delay preterm labor
    • –ADR: most common is tremor

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