neuro 1 cholingeric .txt

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Author:
mhunger
ID:
178659
Filename:
neuro 1 cholingeric .txt
Updated:
2012-10-20 22:41:00
Tags:
neuro cholinergic
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Description:
cholinergic agonists/antagonists
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  1. Direct-acting cholinergic receptor agonists
    • Pilocarpine - used to treat glaucoma
    • Bethanechol - used to treat urinary dysfunction
  2. Indirect-acting cholinesterase inhibitors
    • short duration of action (.5-.8 hours)
    • used to treat Alzheimer's
    • Donepezil (Aricept)
    • Galantamine (Razadyne)
    • Rivastigmine (Excelon)
    • Tacrine (Cognex)
    • Edrophonium (used to test for myasthenia gravis)
  3. Irreversible cholinesterase inhibitors
    • >100 hours
    • used to treat glaucoma
    • Echothiophate
    • Demecarium bromide
  4. Uses for irreversible cholinesterase inhibitors
    • eyes - glaucoma
    • GI tract - postoperative atony
    • urinary tract - neurogenic urinary bladder
    • neuromuscular junction - Myasthenia gravis, curare-induced neuromuscular paralysis
    • heart - supraventricular tachydysrhythmia
    • antimuscarinic intoxication - due to overdose of muscarinic receptor antagonists or tricyclic antidepressants
  5. Toxicity of direct and indirect-acting cholinergic agonists
    • bronchoconstriction
    • salivation
    • lacrimation
    • urination
    • diarrhea
    • nausea
    • vomiting
    • sweating
    • cutaneous vasodilation
    • neuromuscular nicotinic receptors (indirect-acting)
  6. Cholinergic receptor antagonists
    • block parasympathetic nerves
    • enables sympathetic nerves to exert their end-organ effects
  7. Nicotine receptor partial agonist
    • Chantix, varenicline
    • works by blocking the pleasant effects of nicotine achieved from smoking on the brain
    • use: smoking cessation with education and counseling
    • potential adverse behavioral effects: hostility, agitation, depression, suicidal thoughts

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