glucocorticoids and RA

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Author:
buckwild
ID:
178787
Filename:
glucocorticoids and RA
Updated:
2012-10-21 17:31:29
Tags:
glucocorticoids rheumatoid arthritis
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Description:
glucocorticoids/ RA
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  1. indications for glucocorticoids?
    • arthritis
    • SLE (lupus)
    • allergy disorders
    • asthma
  2. adverse effects of glucocorticoids
    • adrenal insufficiency
    • osteoporosis
    • ^ risk for infection
    • muscle wasting
    • thin skin
    • F/E imbalance
    • glucose intolerance
  3. drug interactions with glucocorticoids?
    • NSAIDs
    • insulin, hypoglycemics
    • vaccines
    • thiazide and loop diuretics
  4. special implications re: glucocorticoids?
    • never stop abruptly
    • need higher doses @ times of stress
  5. s/sx of RA?
    • autoimmune inflammatory disorder
    • joint stiffness & pain
    • swollen, tenderness, warm
  6. DMARDs?
    disease modifying antirheumatic drugs
  7. drug therapy for RA?  first choice?
    DMARDs: methotrexate.
  8. sulfasalazine (Azulfidine).  indications? actions? side fx?
    • RA or IBD
    • slows progression of joint deterioration
    • side fx: GI upset, rash, urticaria
  9. methotrexate: adverse fx? 
    • toxicities
    • GI ulcers
    • bone marrow suppression
    • hepatic fibrosis
  10. nursing implications for methotrexate?
    • monitor kidney and liver function.
    • (causes bone marrow suppression)
  11. hydroxychloroquine (Plaquenil): uses, adverse effects?
    • rheumatoid arthritis
    • *monitor for visual disturbances.
    • common to have retinal damage
  12. enteracept (Enbrel)- treatment for? adverse fx?
    • TNF blocker.
    • delays progression of joint damage
    • administered subQ
    • adverse fx from injections. local site reaction, infx
  13. Colchicine: indications, side fx, contraindications?
    • used for acute gouty attacks (if safer drugs dont work)
    • anti-inflammatory.
    • use with caution in cardiac, renal, GI diseases
  14. Allopurinol
    • gout treatment
    • inhibits uric acid production
    • *may prolong halflife of other drugs
  15. Probenecid
    increases excretion of uric acid

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