Two mechanisms by which H. pylori predisposes to peptic ulcer disease.
1. Inflammatory mediators produced by H. pylori inhibit somatostatin secretion (D cells) in the stomach antrum --> Disinhibition of gastrin secretion (G cells) --> Gastrin secretion --> Parietal cell proliferation --> increases the functional capacity of the gastric mucosa to secrete H+ ions
2. Ammonium hydroxide (produced by H. pylori) lowers gastric pH --> gastrin secretion