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What is inside (2) and outside (3) of lipoprotein?
- Inside: cholesterol esters and TAGs
- Outside: free cholesterol + phospholipids and apolipoproteins
What are the 4 main functions of apolipoproteins?
- 1. Structural
- 2. Enzyme activators
- 3. Receptor site binders
- 4. Receptor site blockers
Where do you find apoB100? (3)
VLDL, IDL, LDL
Structural protein for VLDL; ligand for LDL receptor
Where do you find apoB48?
Chylomicrons, chylomicron remnants
Function: structural protein of chylomicrons, lacks LDL-R binding domain and can't bind to LDL R
Where do you find apoE? (5)
Chylomicrons/remnants, VLDL, IDL, HDL
Ligand for binding IDL to LDL-R and LRP
Where do you find Apo A-1?
Structural protein of HDL, activates LCAT/PCAT (forms CE)
What do chylomicrons contain? Chylomicron remnants?
VLDL? IDL? LDL?
Chylomicrons contain B48, apoE, apoAI, apoCII
Remannts: ApoB48, apoE
VLDL, IDL: apoB100, apoE, apoCII, LDL: only apoB100.
HDL: ApoA1, CII, E