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What are some of the causes of GI cancer?
- Alcohol and tobacco use
- Chemical exposure
- Barrett's esophagus (change occures with GERD)
- Achalasia (Lower 2/3 of esophagus loses normal peristaltic activity)
- Plummer-Vision Syndrome (Iron deficient anemia)
Name some signs and symptoms of GI cancer:
- Dysphagia and weight loss
- Chest pain
- Regurgitation and aspiration
4 Detections of GI cancer:
- Chest X-ray
- Barium Swallow
What are the % of the GI tumor locations (upper, lower and middle):
- 10%-25% located in the upper third
- 25%-50% located in the lower third
- 40%-50% located in the middle third
What is the most common pathology in GI cancer?
Squamous Cell (upper and middle)
What pathology is Distal esophagus and GE junction?
Rare GI tumors include:
- Adenoid cystic carcinoma
- Mucoepidermoid carcinoma
What is the Staging (TNM) is based on?
Extension outward (page 783 in textbook)
What is the % 5 year survival?
What are the 3 route of spread?
- Local Invasion
- Distant Metastasis
Which route spreads in longitudinal fashion and skip lesions are present at t significant distance forme primary lesion (submucosal spread)?
Which route of spread is considered Trachoesophageal and bronchoesophageal fistulas?
Where does the distant metastasis spread?
What are the 3 treatment techniques for GI cancer?
- Radiation Therapy
Which treatment technique can treat middle and lower third ONLY, usually reserved for small non-metastatic lesions?
What are some possible complications of having surgery?
- Anastomotic leaks
- Myocardial infarction
- GE reflux
Which treatment method is used in conjunction with radiation for better local control and distant metastatic disease?
Which drugs are used to treat during chemotherapy?
5-Fu and Cisplatin