Cartilage

Card Set Information

Author:
jonas112
ID:
179681
Filename:
Cartilage
Updated:
2012-10-27 15:28:29
Tags:
Histology
Folders:

Description:
Cartilage histology
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  1. Where is hyaline cartilage found in the body? Function?
    • Location
    • 1) Fetal skeletal tissue
    • 2) synovial joints
    • 3) Trachea
    • 4) others

    • Function
    • 1) resists compression (cusioning)
    • 2) lowers friction
    • 3) structural support (e.g. trachea)
    • 4) endochondral ossification
  2. Where is elastic cartilage found in the body? Function?
    • Location
    • 1) pinna of ears
    • 2) larynx
    • 3) auditory tube

    • Function:
    • 1) Provides flexible support
  3. Where is fibrocartilage found in the body? Function?
    • Location:
    • 1) intervertebral discs
    • 2) menisci
    • 3) some joints
    • 4) insertion of tendons

    • Function
    • 1) resists deformation under stress
  4. What are some characteristic features of each cartilage type?
    • hyaline:
    • aggrecan

    • Elastic:
    • Elastin fibres

    • Fibrocartilage:
    • Type I collagen (produced by fibroblasts)
  5. Describe the development and growth of cartilage
    • Development:
    • Develops from the condensation of mesenchyme mesenchymal SC differentiate into chondroblasts

    • appositional growth:
    •  (at the edge) under perichodrium

    • Interstitial growth:
    • Chondroblasts/chondrocytes divide and then secrete matrix (isogenous groups)
  6. Describe the steps in collagen formation.
    • Intracellular
    • 1) transcription of mRNA
    • 2) Translation into polypeptides
    • 3) Hydroxylation of lysines and prolines. Uses vitamin C as a cofactor. this aids in the crosslinking of alpha peptides (making the helix)
    • 4) golgi apparatus modification

    • Extracellular
    • 5) formation of tropocollagen
    • 6) formation of collagen fibril
  7. Describe the structure of the perichondrium and its function in cartilage growth/repair.
    - Fibrous CT

    • - Provides vascular and nervous supply
    • - perichondrial fibroblast-like cells differentiate into collagen II - producing cells
  8. describe the growth, regeneration, and structure of articular cartilage.
    - no perichondrium, therefore there is very limited ability for self repair as mature chondrocytes dont readily divide

    - remember your zonation from M.Sc.

    - damaged cartilage is replaced by fibrovascular cartilage
  9. What is the difference between innervation and blood supply in bone and cartilage?
    - bone is highly vascular while cartilage is avascular

    - cartilage is not innervated while bone is
  10. How does cartilage recieve nutrition and exchange metabolites?
    through diffusion
  11. What causes cartilage to mineralize?
    • 1) advanced age
    • 2) trauma
    • 3) naturally during growth and development

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