Pharm 1

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Author:
nhendri
ID:
179762
Filename:
Pharm 1
Updated:
2012-10-25 16:28:43
Tags:
Pharm
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Description:
Unit5 Peripheral Nervous System Drugs
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  1. Alpha- 1 Receptors Stimulate causes:
    –  Vasoconstriction

    –  Increased peripheral resistance

    •  Both result in increased blood pressure (BP)

    –  Pupil dilation (mydriasis)

    –  Closure of the internal sphincter of the bladder
  2. Alpha - 2 Receptors Stimulatation causes:
    • –  Decreased release of NE, reducing sympathetic
    • outflow from brain

    –  Vasodilation
  3. Beta - 1 Receptor Stimulation causes:
    –  Tachycardia

    –  Increased myocardial contractility

    –  Increased release of renin

    –  Increased lipolysis
  4. Beta - 2 Receptor Stimulation causes:
    • – 
    • ** Bronchodilation

    –  Vasodilation

    –  Slightly decreased peripheral resistance

    –  Increased muscle and liver glycolysis

    –  Increased release of glucagon

    –  Relaxation of uterine smooth muscle

    –  Skeletal muscle contraction
  5. Catecholamines:
    –  Short duration of action

    –  Not effective orally

    –  Do not cross BBB
  6. Non-catecholamines
    –  Long duration of action

    –  Can be given orally

    –  Cross BBB
  7. Anticholinergic Poisoning
    •    Mad as a hatter

    •    Blind as a bat

    •    Red as a beet

    •    Dry as a bone
  8. epinephrine
    Adrenergic Agonists, Nonseletive

    Phamacodynamics: Stimulates CV, Sking & viscera, respiratory receptors

    • Use:
    • Anaphylactic Shock
    • Cardiac Emergencies
    • Asthma
    • Glaucoma

    • Contraindications:
    • Hypersensitivity
    • Active Labor
    • Closed angle glaucoma
    • general anesthesia
    • Severe organic cardiac disease
    • Shock other than anaphylaxis

    • Common Adverse Effects:
    • Fatigue
    • Sleep Disturbances
    • Tremor
    • Weakness
    • Hyperglycemia
    • Tachycardia

    • Serious Adverse Effects:
    • Cardiovascular Stimulation

    • Nursing Interventions:
    • Monitor CV Status Closely
    • Schedule doses to min. sleep disruption
    • Allow appetite and meal times to coincide
  9. prazosin (Minipress)
    • Adrenergic antagonist
    • Alpha

    Pharmacodynamics:

    • -Decreases sympathetic tone of vasculature -Dilate arterioles and veins
    • -Lowers supine and standing BP

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