neuro 2 MS Lou Gehrig.txt

Card Set Information

neuro 2 MS Lou Gehrig.txt
2012-10-25 20:03:57
neuro MS disease Lou Gehrig

MS and Lou Gehrig
Show Answers:

  1. Multiple sclerosis
    • chronic, progressive and degenerative disease
    • affects young adults between 20 and 40
    • frequency of occurrence is rare (0.1%)
    • considered an autoimmune disease
    • disease of the myelin sheath (primary demyelinization)
  2. Possible causes of MS
    • heredity
    • infectious microorganisms
    • trauma
  3. Manifestations of MS
    • motor symptoms: muscle weakness, mild to partial paralysis
    • sensory symptoms: tingling, numbness
    • coordination and balance symptoms: loss of coordination, shaking
    • urinary urgency, incontinence and sexual dysfunction
    • short-term and long-term cognitive deficits
    • periods of remission and exacerbation
  4. Diagnosis of MS
    • no one, specific test
    • blood tests
    • lumbar puncture spinal tap
    • MRI and contrast dye
    • evoke potential test
  5. MS follows one of four potential directions
    • relapsing-remitting
    • progressive relapsing
    • secondary progressive
    • primary progressive
  6. Treatment of MS
    • plasmapheresis
    • glucocorticosteroids to reduce inflammatory spikes during a relapse or flare-up
    • muscle relaxants to reduce spasticity
    • interferons, immunosuppressants and immunomodulators taken long term to reduce frequency and severity of relapses
  7. Lou Gehrig's disease (amyotrophic lateral sclerosis)
    • chronic, terminal neurological disease causing degeneration of motor neurons in the ventral horn of spinal cord
    • affects trigeminal (V), facial (VII) and hypoglossal (XI) cranial nerves
    • affects voluntary muscle movement
    • occurs late in life - 50's, 60's
    • slightly more common in men than women
    • characterized by muscle atrophy in extremities affecting breathing and performing routine tasks
  8. Causes of Lou Gehrig's disease
    • heredity (~10%)
    • unknown (~90%)
  9. Treatment of Lou Gehrig's disease
    • palliative, controlling symptoms
    • neuroprotective medications to slow progression of disease, mechanism unknown
    • centrally-acting muscle relaxants used to treat muscle spasms
    • anxiolytics used to treat anxiety, muscle spasms and seizures
    • muscarinic receptor antagonists used to treat problems with swallowing saliva
    • tricyclic antidepressants used to treat depression and problems with swallowing saliva