A steroid similar to aldostrone; antagonist effect
Blocks the aldo receptor, more specific
Similar in structure to folic acid, block ENaC
Directly blocks apical membrane ENAC channel in the principal cells of the collecting duct.
Potassium-sparing diuretics work by
Blocking Na+ reabsorption in the CCD
Hypokalemic effects of K-sparing diuretcs are due to a decrease in K+ secretion as Na/K exchange occurs in teh collecting duct. Blocking Na entry lowers transepithelial potential reducing driving force for K+ potential.
When combined with other natriuresis from other diuretics, the K+ sparing effect is greatly ______
Which K+-sparing diuretic has less sex steroid actions?
Which K+-sparing diuretic has an onset of action of 2-4 days with full effects not seen for weeks? it is metabolized in the liver.
Which K+-sparing diuretic has diuresis that begins within 2 hours and duration is 24 hours. It is not metabolized and is excreted intact.
Prevent hyperkalemia when giving K+-sparing diuretcs by giving ____
Other diuretics (loop diuretics and thiazide)
Which K+-sparing diuretic can cause gynecomastia, menstrual irregularities, antiandrogen effects?
Adverse effects of K+-sparing diuretics?
Hyperkalemia, metabolic acidosis (infrequent when used with loop and thiazide diuretics)
Which thiazide is better for patients with chronic kidney disease?