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Name the 3 bacteria we studied that contain mycolic acids.
- Mycobacterium (longest)
- Cornybacterium (shortest)
a-alkyl-B-hydroxylated fatty acids
Mycobacterium: Stain, shape
What can cleave mycolic acid chans into C-22 to C-26 fatty acid methyl esters?
Mycobacterium have a high content of what in their DNA?
Mycobacterium growth is
What drug impacts the biosynthesis of mycolic acid
What drug impacts the biosynthesis of arabinogalactan?
Intracellular or extracellular?
- Intracellular in unactivated macrophages.
- Prevents fusion of phagosome with lysosomes
Pathology of tuberculosis is due to?
CMI response (disease primarily from host response to infection rather than specific virulence factors).
Natural reservoir of TB?
Humans (1/3 of worl is infection)
TB migrates to ____ lymph nodes. Can see granulomas and _____
- hilar lymph nodes
- granulomas and foam cells
Lesion in lung (tubercle/small granuloma) + enlarged lymph nodes
Most TB cases are restricted to the ____ in immune competent persons
Tuberculin skin test is read by
presence or absence of induration at injection site
Alternative to TB skin test, based on quantificatoin of interferon-y
Quiantiferon-TB Gold Test
- Fix bacteria to microscope slide
- Carbofuschin (w/ or w/o heat)
- Decolarize with acid alcohol
- Counter stain (methylene blue or brilliant green)
NTM (Nontuberculous Mycobacterum)
Swimming pool granuloma
Chronic infectin of skin an peripheral nerves
Two types of leprosy:
- Tuberculoid: benign, non-progressive
- Lepromatous: Malignant, progressive
Which type of leprosy has few AFB in lesions and a positive lepromin skin test?
Tuberculoid leprosy (strong CMI and normal Ig levels)
Which type of leprosy has many AFB in skin lesions and anegative lepromin skin test?
Lepromatous leprosy (Deficient CMI, strong Ab response)